中国组织工程研究2016，Vol.20Issue(38)：5737-5744,8.DOI:10.3969/j.issn.2095-4344.2016.38.017
细胞外基质来源支架在软骨组织工程中的应用
Extracellular matrix-derived scaffolds for cartilage tissue engineering
摘要
Abstract
BACKGROUND:At present, a variety of extracel ular matrix-derived scaffolds have been successful y applied for cartilage tissue engineering in experiment and clinical practice. OBJECTIVE:To summarize the application and research status of extracel ular matrix-derived scaffolds in cartilage tissue engineering. METHODS:A computer-based online search in PubMed, CNKI, CqVip and WanFang databases was performed using the keywords of“tissue engineering, cartilage, extracel ular matrix, scaffolds”in English and Chinese, respectively. A total of 1 140 literatures were retrieved, and final y 65 eligible literatures were included. RESULTS AND CONCLUSION:In terms of the components, extracel ular matrix-derived scaffolds are divided into monomeric natural polymers, mixed natural polymers, natural polymers compositing with synthetic polymers as wel as acel ular extracel ular matrix-derived materials. Extracel ular matrix-derived scaffolds hold good biocompatibility and degradability, and can promote proliferation and differentiation of choncrodytes;therefore, they as good bionic scaffolds have been applied for cartilage tissue engineering in clinical practice, However, poor mechanical properties and difficulty to molding should never be ignored. Further research should focus on improving the preparation technology by combining synthetic materials with extracel ular matrix-derived scaffolds for cartilage tissue engineering.关键词
生物材料/软骨生物材料/细胞外基质/组织工程/软骨/支架/国家自然科学基金分类
医药卫生引用本文复制引用
肖统光,张一民,郭维民,刘舒云,杨建华,郭全义..细胞外基质来源支架在软骨组织工程中的应用[J].中国组织工程研究,2016,20(38):5737-5744,8.基金项目
国家自然科学基金(81472092)；国家高技术发展研究计划(863计划)(2012AA020502) （81472092）
