原子能科学技术2016，Vol.50Issue(9)：1565-1569,5.DOI:10.7538/yzk.2016.50.09.1565
131I标记卟啉化合物结合光动力治疗对肿瘤生长的抑制作用
Antiblastic Effect of Porphyrin Labeled with 131 I Combined with Photodynamic Therapy to Tumor
摘要
Abstract
The porphyrins of TPPOH and TPPNH2 were labeled with 131I to obtain 131I‐TPPOH and 131I‐TPPNH2 .The human hepatocellular carcinoma cell line SMMC‐7721 bearing nude mice was developed . The labeled compounds were injected into tumors directly to investigate the antiblastic effect of porphyrin ,131 I and photodynamic therapy (PDT) to tumor .131I‐TPPOH and 131I‐TPPNH2 still remain in tumors after 14 d post injection ,and it shows that the two porphyrins have good affinity to tumors .By the function of β‐ray and PDT ,the two 131 I labeled porphyrins show a very effective anti‐blastic effect to tumors .It is possible to develop a novel solid tumor therapy ligand combined“porphyrin+ 131 I+PDT” .关键词
卟啉/131 I/光动力治疗/肿瘤Key words
porphyrin/131 I/photodynamic therapy/tumor分类
能源科技引用本文复制引用
王关全,郭欣,宋虎,周志军,魏洪源,何佳恒,刘国平,罗顺忠..131I标记卟啉化合物结合光动力治疗对肿瘤生长的抑制作用[J].原子能科学技术,2016,50(9):1565-1569,5.基金项目
国家科技重大专项资助项目（2014ZX09507007-004）；国家科技支撑计划资助项目 （）
