中国当代儿科杂志2016，Vol.18Issue(10)：947-952,6.DOI:10.7499/j.issn.1008-8830.2016.10.006
早产儿血清促红细胞生成素水平与脑损伤的关系
Relationship between serum erythropoietin levels and brain injury in preterm infants
摘要
Abstract
ObjectiveTo study the relationship between the levels of erythropoietin (EPO) in serum and brain injury in preterm infants.MethodsThree hundred and four preterm infants (gestational age: 28-34 weeks) born between October 2014 and September 2015 were enrolled in this study. Brain injury was diagnosed using cerebral ultrasound and MRI. The levels of EPO, S100 protein, neuron-speciifc enolase (NSE) and myelin basic protein (MBP) in serum were detected using ELISA. To compare the incidence of brain injury in different serum EPO levels in preterm infants, and the relationship between brain injury and serum EPO levels was analyzed.ResultsThe incidence rate of brain injury in preterm infants was 41.1% (125/304). The incidence rate of brain injury in the low EPO level group was signiifcantly higher than that in the middle-high EPO level groups (P<0.01). The serum levels of S100 protein, NSE, and MBP in the brain injury groups were signiifcantly higher than in the control group (P<0.01). The serum EPO levels were negatively correlated with serum S100 protein concentration and NSE levels (P<0.05). According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants.ConclusionsThere is a higher incidence rate of brain injury in preterm infants with lower serum EPO levels. The serum EPO levels may be correlated with brain injury in preterm infants.关键词
促红细胞生成素/脑损伤/危险因素/早产儿Key words
Erythmpoietin/Brain injury/Risk factor/Preterm infant引用本文复制引用
陈光福,孔琦,刘荣添,李辉桃,黄进洁,王章星,李赟,杨传忠,吴本清,刘文兰,刘丽辉..早产儿血清促红细胞生成素水平与脑损伤的关系[J].中国当代儿科杂志,2016,18(10):947-952,6.基金项目
深圳市科技计划项目（JCYJ20140414170821145）。 （）
