中国当代儿科杂志2016，Vol.18Issue(10)：991-994,4.DOI:10.7499/j.issn.1008-8830.2016.10.015
肥胖对哮喘预测指数阳性喘息婴幼儿治疗效果的影响
Effect of obesity on treatment outcome of asthma predictive index-positive infants and young children with wheezing
摘要
Abstract
ObjectiveTo study the effect of obesity on the treatment outcome of asthma predictive index (API)-positive infants and young children with wheezing.MethodsA total of 208 API-positive infants and young children with wheezing were enrolled. According to the Kaup index, the patients were divided into an obese group (n=93) and a non-obese group (n=115). The patients were given multimodality therapy in an acute episode of wheezing and aerosol inhalation of inhaled corticosteroid (ICS) budesonide suspension in the remission stage. The dose of ICS was adjusted according to clinical control. The patients were treated for 6 months, and were followed up at 2 weeks after treatment and once per month afterwards.ResultsAt 2 weeks and 1 month after treatment, the obese group had signiifcantly lower remission rates of clinical symptoms than the non-obese group (35.5%/75.3% vs 53.0%/87.8%;P<0.05). Compared with the non-obese group, the obese group had signiifcantly higher incidence rates of wheezing at 3 and 6 months after treatment and a signiifcantly higher proportion of patients who visited the emergency service or were hospitalized due to wheezing within 6 months (P<0.05).ConclusionsObesity can inhibit the response to ICS treatment in API-positive infants and young children with wheezing.关键词
肥胖/哮喘预测指数/喘息/治疗效果/婴幼儿Key words
Obesity/Asthma predictive index/Wheezing/Treatment outcome/Infant and young child引用本文复制引用
陈波,冯帅,尹晓文..肥胖对哮喘预测指数阳性喘息婴幼儿治疗效果的影响[J].中国当代儿科杂志,2016,18(10):991-994,4.基金项目
国家自然科学基金（21567024）。 （）
