中国当代儿科杂志2016，Vol.18Issue(10)：1009-1012,4.DOI:10.7499/j.issn.1008-8830.2016.10.019
脓毒性休克患儿血清皮质醇和促肾上腺皮质激素水平的变化及临床意义
Changes in serum cortisol and adrenocorticotropic hormone in children with sepsis shock and their clinical signiifcance
摘要
Abstract
ObjectiveTo study the changes in serum levels of cortisol and adrenocorticotropic hormone (ACTH) in children with septic shock (SS) and to explore their relationship with the disease severity and prognosis.Methods Twenty-ifve children with decompensated SS and 24 children with early SS were enrolled. Serum cortisol and ACTH levels were determined on admission and days 3 and 8 after admission. Twenty-five healthy children were used as the control group. The children with decompensated SS were further divided into death group (n=5) and survival group (n=20) based on their clinical outcome.ResultsOn admission, the decompensated SS and early SS groups had signiifcantly higher serum cortisol and ACTH levels than the control group (P<0.05), and the decompensated SS group had signiifcantly higher serum cortisol and ACTH levels than the early SS group. On day 3 after admission, the decompensated SS group had signiifcantly higher serum cortisol and ACTH levels than the early SS and control groups (P<0.05), and the early SS group had a signiifcantly higher serum ACTH level than the control group (P<0.05). Among the children with decompensated SS, the death group had significantly higher serum cortisol and ACTH levels than the survival group on admission (P<0.01); on day 3 after admission, the death group still had a significantly higher serum cortisol level than the survival group (P<0.01).ConclusionsChildren with SS have increased serum cortisol and ACTH levels, which are associated with the disease severity. A persistent high serum cortisol level indicates a poor prognosis. Dynamic monitoring of serum cortisol and ACTH levels in children with SS is of great signiifcance in evaluating the disease severity and prognosis.关键词
脓毒性休克/皮质醇/促肾上腺皮质激素/预后/儿童Key words
Septic shock/Cortisol/Adrenocorticotropic hormone/Prognosis/Child引用本文复制引用
林海,王子敬,王世彪,康育兰..脓毒性休克患儿血清皮质醇和促肾上腺皮质激素水平的变化及临床意义[J].中国当代儿科杂志,2016,18(10):1009-1012,4.基金项目
福建省自然科学基金资助项目（2014J01400）；福建省妇幼保健院院内科研课题资助项目（13-32）。 （）
