颈总动脉穿刺法制备大鼠大脑中动脉栓塞模型OA北大核心CSCDCSTPCD
A modified method for common carotid artery puncture in the establishment of a rat model of middle cerebral artery occlusion
目的：对颈总动脉穿刺法及传统线栓法制备大鼠大脑中动脉栓塞（ middle cerebral artery occlusion， MCAO）模型的时效性、成功率、死亡率比较。方法将32只雄性大鼠随机分为颈总动脉穿刺法组与传统线栓法组，将线栓从颈总动脉插入，栓塞大脑中动脉。采用Bederson神经功能评分标准，于术后24 h进行神经功能评分，并统计24 h成功率及死亡率。结果颈总动脉穿刺法和传统手术方法制备大鼠MCAO模型的插线栓时间、成功率、死亡率…查看全部>>
Objective To compare the timeliness, success and mortality rates between the modified carotid artery puncture method ( MCAPM) and standard suture method ( SSM) in the establishment of rat model of a middle cerebral ar⁃tery occlusion ( MCAO) . Methods Thirty⁃two male rats were randomly and equally assigned into MCAPM group and SSM group. The MCAO models were established by inserting a thread into the common carotid artery ( CCA) . 24 h after modeling, the rat…查看全部>>
刘华;刘月美;关芮;徐昭;朱文增
中国中医科学院广安门医院，北京 100032 北京中医药大学针灸推拿学院，北京 100029北京师范大学生命科学学院，北京 100875中国中医科学院广安门医院，北京 100032 北京中医药大学针灸推拿学院，北京 100029
生物科学
脑缺血大脑中动脉栓塞线栓法大鼠
Cerebral ischemiaMiddle cerebral artery occlusion, MCAOStandard suture methodRat
《中国实验动物学报》 2016 (4)
399-402,4
国家自然科学基金面上项目（81273841）。
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