中国比较医学杂志2016，Vol.26Issue(8)：20-24,5.DOI:10.3969/j.issn.1671-7856.2016.08.002
复杂性状遗传 CC 小鼠在传染病领域的应用及研究进展
Application and Research Progress of Collaborative Cross mice in Infectious Disease Area
摘要
Abstract
Animal model plays an important role in prevention and control of infectious disease, which could link basic research in laboratory with clinical diagnosis and treatment for human patients.Mouse is the most widely used animal model of infectious disease, however, adult immunocompetent mice are resistant to some pathogens.The highly genetically diverse Collaborative Cross (CC) mice could recapitulate many of the genetic characteristics of an outbred population, such as humans.Based on this, this review will focus on the application and research progress of CC mice in infectious disease (including viruses, bacteria, fungi etc.), which could provide useful reference data for expansion of animal model resource bank, and implement of precision medicine of major and new emerging infectious diseases.We hope this review could serve as a modest spur to induce other researchers to come forward with their valuable contributions.关键词
复杂性状遗传小鼠/传染病/易感性/动物模型Key words
Collaborative Cross mice/Infectious disease/Susceptibility/Animal model分类
医药卫生引用本文复制引用
许黎黎,秦川..复杂性状遗传 CC 小鼠在传染病领域的应用及研究进展[J].中国比较医学杂志,2016,26(8):20-24,5.基金项目
十二五科技重大专项（2012ZX10004501－004）；国家自然科学基金（31370203）；北京市自然科学基金（7142106），协和科技新星培养项目。 （）
