中国比较医学杂志2016，Vol.26Issue(8)：25-29,5.DOI:10.3969/j.issn.1671-7856.2016.08.000
复杂性状遗传 CC 小鼠--肿瘤研究新平台
Collaborative Cross mice as a novel platform in cancer research
摘要
Abstract
Cancer is a general term of a series of complex traits of the disease triggered by the body cells losing their normal regulation of excessive proliferation, which essentially is a genetic disease.Recombinant inbred strain (RI) mouse generated from one pair of founders has been widely used in traditional tumor model.However, RI has many limitations on the statistic efficiency because of the small scale and lacking of allele diversity.The Collaborative Cross (CC) was designed to generate hundreds of recombinant inbred lines by 8 divergent strains of mice.CC mice embody a tremendous amount of natural genetic variation in different sub-strains of mouse and the single nucleotide polymorphism is four times of the traditional experimental mice.The high-genetic diversity and large scale population enables CC mice simulates the differences of individual susceptibility to the pathogeny or the therapies,thus provides a better research tool and information platform for expediting discovery of genes and genes function in human complex traits diseases.This review summarizes our current knowledge of this field, including methodologic aspects, applications, challenges and limitations, and utilization for cancer research.关键词
复杂性状遗传小鼠(CC 小鼠)/遗传多样性/个体易感性/肿瘤Key words
Collaborative Cross/Genetic diversity/Individual sensitivity/Cancer分类
医药卫生引用本文复制引用
李克娟,高苒..复杂性状遗传 CC 小鼠--肿瘤研究新平台[J].中国比较医学杂志,2016,26(8):25-29,5.基金项目
中国医学科学院基本科研业务费专项资助项目（DWS201402）。 （）
