中国比较医学杂志2016，Vol.26Issue(8)：47-52,6.DOI:10.3969/j.issn.1671-7856.2016.08.007
遥测方法对比传统安全药理学方法的优势及应用
Advantages and application of telemetry compared with the traditional methods in safety pharmacology
摘要
Abstract
Objective To prove the advantages of telemetry by comparing with the traditional methods in safety pharmacology.Methods To monitor continuously the heart rate, respiratory rate, blood pressure and ECG of Beagle dogs by traditional and telemetry methods respectively, analyze and compare the changes between anesthetized and conscious dogs before and after feeding.Results Maintenance of anesthesia changed significantly the heart rate, respiratory rate, blood pressure and QT interval in the ECG of animals.The changes of physiological indicators in 24 h is not obvious in conscious animals, and showed a certain biorhythm.Compared with the conscious animals, the anesthetized dogs’ heart rate was significantly higher, blood pressure increased significantly, QRS and QTcf interval prolonged significantly, respiratory frequency decreased, heart rate increased significantly after feeding, and QTcf interval extended very significantly.Conclusions Traditional methods in safety pharmacology affect animal physiological indicators such as heart rate, blood pressure, respiratory rate and QT interval, which affect the objectivity of drug evaluation.Using conscious animals by telemetry can reduce these errors, however, the interference from outside should be eliminated.关键词
Beagle 犬/遥测/安全药理Key words
Beagle dog/Telemetry/Safety pharmacology分类
医药卫生引用本文复制引用
孙晶晶,周泉,齐珍珍,郭秋平..遥测方法对比传统安全药理学方法的优势及应用[J].中国比较医学杂志,2016,26(8):47-52,6.基金项目
广州市科信局市科研条件建设（编号穗科条［2009］5－11，穗科条［2013］277－1）；广州市科信局生物产业重大专项（编号201300000053）。 （）
