中国比较医学杂志2016，Vol.26Issue(8)：59-65,7.DOI:10.3969/j.issn.1671-7856.2016.08.009
尿通卡克乃其片大鼠长期毒性实验的血液指标变化
A long-term study of the toxicity of an Uyghur medicine, Kursi Kaknaq, on hematological parameters in rats
摘要
Abstract
Objective To investigate the long-term toxicity of an Uyhgur medicine, Kursi Kaknaq, on hematological parameters in the rats.Methods A total of 120 healthy Sprague-Dawley rats were randomly divided into the control, low dose (0.32 g/kg・ d ), moderate dose (1.6 g/kg・ d) and high dose (3.2g/kg・ d) Kursi Kaknaq groups.The drug was given orally, 6 days per week for 180 days.The control group was given 0.5% sodium carboxymethyl cellulose suspension. Results No death was recorded in the rats and no obvious toxic events were observed during the experiment. Hematological parameters including RBC, HGB, MCH, MCHC, LYMP%, WBC, and PLT; biochemical parameters including ALT,AST, ALP, GLU, BUN, ALB ,TBIL, Crea, TCHO, TG, and CK; electrolyte time parameters such as K+, Na+, Cl-and prothrombin time(PT) showed statistically significant differences (P <0.05 and P <0.01), but did not show time and dose effect regularity, and no pathological significance.Conclusions No obvious toxic effects on hematological parameters are observed in the SD rats treated with Kursi Kaknaq at doses of 0.32 g, 1.6 g, or 3.2 g (crude drug) /kg・ d orally administered for 180 days, indicating that this drug is safe for long-term clinical use.关键词
尿通卡克乃其片/大鼠/长期毒性/血液指标Key words
Kursi Kaknaq, Uyghur medicine/Rats/Chronic Toxicity, Blood parameters分类
医药卫生引用本文复制引用
热比姑丽・伊斯拉木,阿布都吉力力・阿布都艾尼,冷英莉,王静..尿通卡克乃其片大鼠长期毒性实验的血液指标变化[J].中国比较医学杂志,2016,26(8):59-65,7.基金项目
新疆维吾尔自治区专利实施计划项目基金（编号2009002）；新疆维吾尔自治区乌鲁木齐市科学技术计划项目基金（编号C111110002）。 （）
