中国比较医学杂志2016，Vol.26Issue(8)：91-95,5.DOI:10.3969/j.issn.1671-7856.2016.08.015
不同来源高度免疫缺陷小鼠微卫星 DNA 遗传检测的分析
Genetic monitoring and analysis of highly immunodeficient mice from different sources by microsatellite DNA markers
范涛 1王洪 1魏杰 1周舒雅 1岳秉飞 1李保文1
作者信息
- 1. 中国食品药品检定研究院，北京 100050
- 折叠
摘要
Abstract
Objective To test and analyze the genetic background of highly immunodeficient mice from different sources.Methods Four highly immunodeficient mouse strains from different sources of NOD background were collected. 30 microsatellite DNA sites were detected, and the genotype can be displayed by gel electrophoresis and STR scanning. Results 17 microsatellite sites exhibit polymorphism in 20 mice of the four groups.There were 30 homozygous loci in the mice of groups A and B, and heterozygous in the other two groups.The genetic distance is minimum between groups A and B, showing a higher genetic similarity.Conclusions The genetic backgrounds are different in highly immunodeficient mice from different sources.关键词
免疫缺陷小鼠/微卫星/遗传质量Key words
Immunodeficient mice/Microsatellite/Genetic quality/Mice分类
医药卫生引用本文复制引用
范涛,王洪,魏杰,周舒雅,岳秉飞,李保文..不同来源高度免疫缺陷小鼠微卫星 DNA 遗传检测的分析[J].中国比较医学杂志,2016,26(8):91-95,5.
