中国比较医学杂志2016，Vol.26Issue(9)：1-4,4.DOI:10.3969/j.issn.1671-7856.2016.09.001
复杂性状遗传CC小鼠的特点及实际应用中的提示
The character of Collaborative Cross mice and tips for its application
李欣悦 1向志光1
作者信息
- 1. 中国医学科学院医学实验动物研究所，北京 100021
- 折叠
摘要
Abstract
Laboratory animals support the life science research. Based on their clear genetic, immune background, mice have been widely used. In the Post⁃genomics era, a great deal of genetic engineering mouse models, including those transgenic mice and gene targeted mice had been developed to study some a specific gene. However, most human diseases are not controlled by a single gene; besides the environmental factors, multiple genetic factors can influence the development of human diseases. The complex multi⁃gene traits research in life science put forward new challenges to the laboratory animals. To meet this challenge, scientists have proposed to develop a new mouse resource called the Collaborative Cross ( CC) mice. This paper will review the background and character of CC mice, and gives some suggestions for its application.关键词
重组杂交系小鼠/多基因复杂性状/CC小鼠Key words
Recombinant inbrid strain mouse/Complex multi-gene traits/Collaborative Cross mice分类
医药卫生引用本文复制引用
李欣悦,向志光..复杂性状遗传CC小鼠的特点及实际应用中的提示[J].中国比较医学杂志,2016,26(9):1-4,4.
