中国现代医学杂志2016，Vol.26Issue(18)：30-33,4.DOI:10.3969/j.issn.1005-8982.2016.18.006
小剂量低分子肝素联合硫酸镁治疗重度子痫前期对血清和胎盘中病情相关分子的调节作用
Regulation effect of small doses of low molecular weight heparin combined magnesium sulfate treatment on serum and placental disease-related molecules of severe preeclampsia patients
戴薇 1许吟 1马星卫 1张莉 1仲青1
作者信息
- 1. 贵州省人民医院 产科，贵州 贵阳 550002
- 折叠
摘要
Abstract
Objective To analyze the regulation effect of small doses of low molecular weight heparin combined magnesium sulfate treatment on serum and pl acental disease-related molecules of severe preeclampsia patients. Methods Sixty-eight cases of severe preeclampsia patients between July 2012 to July 2014 in our hospital were chosen as research subjects and randomly divided into observation group and control group. The control group patients received magnesium sulfate treatment alone, the observation group patients received small doses of low molecular weight heparin combined magnesium sulfate treatment. The serum and placental levels of kallikrein expression, PAPP-A, SPI, PLGF, HPL, TGF-β1, VCAM-1 and E-selectin were compared between the two groups. Results The serum and placental kallikrein and TGF-β1 levels of the observation group were significantly higher than those of the control group ( < 0.05); while the serum and placental PAPP-A, VCAM-1 and E-selectin levels were lower than those of the control group ( < 0.05). Conclusions In severe preeclampsia patients, treatment with pancreatic kallikrein and magnesium sulfate can promote endogenous kallikrein expression, reduce the levels of gestational hypertension-related predictive factors, weaken the invasive capacity of cytotrophoblast cells.关键词
重度子痫前期/小剂量低分子肝素/硫酸镁/病情相关分子Key words
severe preeclampsia/small dose of low molecular weight heparin/magnesium sulfate/disease-related molecule分类
医药卫生引用本文复制引用
戴薇,许吟,马星卫,张莉,仲青..小剂量低分子肝素联合硫酸镁治疗重度子痫前期对血清和胎盘中病情相关分子的调节作用[J].中国现代医学杂志,2016,26(18):30-33,4.
