中国现代医学杂志2016，Vol.26Issue(18)：34-38,5.DOI:10.3969/j.issn.1005-8982.2016.18.007
血清β2微球蛋白与2型糖尿病患者认知功能障碍的相关性研究*
Association of serumβ2-microglobulin with cognitive function in type 2 diabetes patients*
摘要
Abstract
Objective To investigate the association of β2-microglobulin (β2-MG) with cognitive dysfunction in T2DM patients. Methods In this study 186 T2DM patients cared at Tangshan Gongren Hospital and 150 controls without T2DM from the Medical Examination Center from June 2015 to October 2015 were recruited. Data on demographic characteristics and clinical parameters were collected. β2-MG was measured by immunocapture act. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results Serum β2-MG of the T2DM patients was higher than that of the controls ( < 0.01). RBANS scores in the T2DM patients were lower than those of the controls on the total score and all subtest scores ( <0.05). In the T2DM patients, the immediate memory, visuospatial/constructional, language, attention and delayed memory scores and the total score of the patients with higher β2-MG were lower than those of the patients with lower β2-MG ( < 0.05). In the T2DM patients, β2-MG level was negatively correlated with immediate memory, visuospatial/constructional, language, attention and total scores ( < 0.01). Conclusions Increased β2-MG level may be one of the risk factors for cognitive dysfunctiones of T2DM patients.关键词
β2微球蛋白/2型糖尿病/认知Key words
β2-microglobulin/type 2 diabetes mellitus/cognition分类
医药卫生引用本文复制引用
张志月,郝向波,刘晓爽,周玉梅,房辉,李玉凯,王耕银,邱明月,马一嘉,张馨心,张红蕊,甄艳凤..血清β2微球蛋白与2型糖尿病患者认知功能障碍的相关性研究*[J].中国现代医学杂志,2016,26(18):34-38,5.基金项目
河北省自然科学基金资助项目 （）
