摘要
Abstract
Objective To explore serum levels of uric acid, bilirubin and lipoprotein in elderly patients with acute ischemic stroke and comprehensively analyze the factors correlated to acute ischemic stroke. Methods A total of 114 acute ischemic stroke patients (AIS group) and 90 matched normal people receiving health examination (control group) between January 2014 and December 2015 were collected. The 24-h fasting serum levels of uric acid, total bilirubin, triglyceride, blood sugar, high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1) and total cholesterol were tested in the AIS patients, and compared with those in the control group. Results BMI, triglyceride, uric acid, blood sugar, LDL, ApoB/ApoA1 ratio, total cholesterol, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the AIS group were significantly higher than those of the control group ( <0.01). Total bilirubin and HDL of the AIS group were lower than those of the control group ( <0.01). Uric acid was positively correlated with BMI, triglyceride, blood sugar, LDL, ApoB/ApoA1 ratio and DBP ( <0.01), but negatively correlated with total bilirubin and SBP ( <0.01). Total bilirubin was in a positive correla-tion with HDL ( < 0.01), but in negative correlations with uric acid, triglyceride, blood sugar, LDL, ApoB/ApoA1 ratio, total cholesterol, SBP and DBP ( <0.01). LDL was in positive correlations with BMI, uric acid, blood glucose, ApoB/ApoA1 ratio and total cholesterol ( < 0.01), but in negative correlations with age, triglyceride and HDL ( <0.01). Conclusions The high levels of uric acid, total bilirubin and lipoprotein are the independent risk factors for acute ischemic stroke in elderly patients. Synergies of the three independent risk factors with other related factors play significant roles in the development of elderly acute brain stroke.关键词
急性缺血性脑卒中/尿酸/总胆红素/脂蛋白Key words
acute ischemic stroke/uric acid/total bilirubin/lipoprotein分类
医药卫生
