中国现代医学杂志2016，Vol.26Issue(18)：68-74,7.DOI:10.3969/j.issn.1005-8982.2016.18.014
胰岛素泵强化治疗不同病程初诊2型糖尿病的临床观察及随访研究*
Therapeutic effect of insulin pump on newly-diagnosed type 2 diabetes in different course
摘要
Abstract
Objective To study the effects of transient intensive insulin therapy [continuous subcutaneous insulin infusion (CSII)] on glycemic control, isletβ-cell function and diabetes remission rate in newly-diagnosed type 2 diabetes patients of different course. Methods In accordance with the disease course, 60 patients with type 2 diabetes were divided into three groups (group A:1-6 months, 6 months<group B<1 year, group C≥1 year). After CSII, the patients were given insulin or oral hypoglycemic drugs according to comprehensive judgment. All the patients were given 1 year of follow-up and outpatient care every 3 months. Intravenous glucose tolerance tests were done, and blood glucose, insulin and proinsulin were measured before and after therapy and during 1-year follow-up. Results All the patients achieved target glycemic control and improvement of β-cell function after treatment ( < 0.01). The patients of the groups A and B had better improvement of β-cell function with lower insulin dosage and shorter time to obtain glycemic control compared to the patients of the group C ( <0.01). During 1-year follow-up, the remission rate of the groups A and B was significantly higher than that of the group C ( <0.05). The isletβ-cell function at 3 months and 1 year of follow-up had no statistical differences among the three groups ( > 0.05). Conclusions Transient intensive insulin therapy has favorable outcomes on recovery and maintenance of β-cell function and pro-tracted glycemic remission in patients with newly-diagnosed type 2 diabetes. Furthermore, the patients with short course of disease (≤1 year) achieved better improvement of β-cell function with lower insulin dosage and shorter time to restore standard glucose level. The continuing hypoglycemic effect after 1 year might be due to the effect of . Some patients can even achieve long-term complete clinical remission without using any medicine. The study may provide theoretical basis for clinical work.关键词
2型糖尿病/胰岛素泵/强化治疗/胰岛β细胞功能/糖尿病缓解期Key words
type 2 diabetes/insulin pump/intensive therapy/β-cell function/remission stage分类
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徐有伟..胰岛素泵强化治疗不同病程初诊2型糖尿病的临床观察及随访研究*[J].中国现代医学杂志,2016,26(18):68-74,7.基金项目
青海省科学技术厅项目 （）
