摘要
Abstract
Objective To explore the change and significance of serum fat factors and inflammatory cytokines in children with metabolic syndrome (MS). Methods In this study 50 metabolic syndrome children (MS group), 50 simple obesity children (simple obesity group) and 50 normal children having physical examination (normal control group) were included. They all accepted regular physical examination and biochemical examination. The serum fat factors including adiponectin and leptin and serum inflammatory factors including tumor necrosis factor alpha (TNF-α), hypersensitive C-reactive protein (hs-CRP) and interleukin 6 (IL-6) were checked with double resistant sandwich enzyme-linked immunosorbent assay (ELISA). The correlations of serum fat factors and inflammatory factors with physical and biochemical test results were analyzed. Results The levels of FBG, TC, TG, LDL-C, SBP, DBP, BMI, TNF-α, hs-CRP and IL-6, and waist-to hip ratio in the MS group were significantly higher while the levels of HDL-C and adiponectin were significantly lower than those of the simple obesity group and the normal control group ( <0.05). The levels of TC, LDL-C, SBP, DBP, BMI, TNF-α, hs-CRP and IL-6 were significantly higher while the adiponectin level was significantly lower in the simple obesity group than those in the normal control group ( <0.05). However, the leptin level had no statistical differences among the three groups ( >0.05). Correlation analysis showed that the serum hs-CRP was positively correlated to TC, SBP, BMI and waist-to-hip ratio; the serum IL-6 was positively correlated to TC, DBP, BMI and waist-to-hip ratio; and the adiponectin was negatively correlated to TC and LDL-C. Conclusions Serum fat factors and inflammatory factors can be used as the indicators of occurrence and development of MS in children.关键词
儿童/代谢综合征/脂肪因子/炎症因子Key words
children/metabolic syndrome/fat factor/inflammatory cytokine分类
医药卫生
