南方医科大学学报2016，Vol.36Issue(9)：1231-1236,6.DOI:10.3969/j.issn.1673-4254.2016.09.12
血清脂肪因子omentin-1、chemerin的水平与妊娠期糖尿病的相关性
Correlation of serum omentin-1 and chemerin with gestational diabetes mellitus
摘要
Abstract
Objective To investigate the relationship of serum omentin-1 and chemerin with gestational diabetes mellitus (GDM). Methods Serum levels of omentin-1 chemerin, glycolipids biochemical index, inflammation index, fasting insulin (FINS), and insulin resistance indexes (HOMA-IR) were determined in 85 women with GDM and 85 pregnant women with normal glucose tolerance (NGT). Results BMI, FPG, hs-CRP, blood lipids, blood glucose, FINS, HOMA-IR and serum chemerin level were all significantly higher while serum omentin-1 significantly lower in GDM group than in NGT group (P<0.05). In both groups, serum omentin-1 level was significantly lower and serum chemerin was significantly higher in obese subjects than in the non-obese subjects (P<0.05). Obesity before delivery and/or HOMA-IR ≥2 was associated with a significantly decreased serum omentin-1 level; serum chemerin increased significantly in obese women before delivery but was not associated with HOMA-IR. Serum omentin-1 level was positively correlated with HDL but inversely with BMI (at pregnancy and before delivery), FPG, FINS and HOMA-IR;Chemerin was positively correlated with TC, TG, hs-CRP and FPG;serum omentin-1 and chemerin levels were not significant correlated (P=0.301). In women with GDM, BMI at pregnancy, TG, FPG, and FINS were all independent factors affecting serum omentin-1; TG, LDL, and hs-CRP were independent factors affecting serum chemerin. Conclusion An decreased serum omentin-1 can be indicative of glucose and lipid metabolism disorder and insulin resistance, and an increased serum chemerin level indicates hyperlipidemia and chronic inflammation in pregnant women. Both of the adipokines are closed associated with GDM and probably participate in the occurrence and development of GDM.关键词
脂肪因子/omentin-1/chemerin/妊娠期糖尿病Key words
adipokines/omentin-1/chemerin/gestational diabetes mellitus引用本文复制引用
潘宝龙,马润玫..血清脂肪因子omentin-1、chemerin的水平与妊娠期糖尿病的相关性[J].南方医科大学学报,2016,36(9):1231-1236,6.基金项目
国家自然科学基金（81160082） Supported by National Nature Science Foundation of China (81160082) （81160082）
