临床与病理杂志2016，Vol.36Issue(8)：1092-1095,4.DOI:10.3978/j.issn.2095-6959.2016.08.009
BRAF基因突变在甲状腺乳头状癌中的临床意义
Clinical significance of BRAF mutation in papillary thyroid carcinoma
赵苏苏 1余泽前 2李惠 1孙怡 1王剑蓉 1章宜芬1
作者信息
- 1. 南京中医药大学附属医院江苏省中医院病理科，南京 210029
- 2. 东南大学附属中大医院普通外科，南京 210009
- 折叠
摘要
Abstract
Objective: To explore the correlation between BARF V600E mutation and papillary thyroid cancer.Methods: hTe BARF V600E mutation status was analyzed in 63 cases of papillary thyroid cancer and 45 cases of other types of thyroid diseases by PCR and direct sequencing technology.Results:32 out of 63 papillary thyroid cancer cases had BARF V600E mutation. However, no mutation was found in tissues from 45 cases of other types of thyroid diseases. BARF V600E mutation was signiifcantly associated with tumor size and regional lymph node metastasis (P<0.05).Conclusion: BARF V600E mutation is associated with the pathogenesis, tumor size and regional lymph node metastasis in papillary thyroid cancer.关键词
甲状腺乳头状癌/BRAF/基因突变Key words
papillary thyroid cancer/BARF/gene mutation引用本文复制引用
赵苏苏,余泽前,李惠,孙怡,王剑蓉,章宜芬..BRAF基因突变在甲状腺乳头状癌中的临床意义[J].临床与病理杂志,2016,36(8):1092-1095,4.
