临床与病理杂志2016，Vol.36Issue(8)：1148-1155,8.DOI:10.3978/j.issn.2095-6959.2016.08.020
2772例肠肿瘤临床病理特征分析
2 772 cases of clinicopathological characteristics analysis of intestine neoplasm
王海艳 1尉承泽 2许春伟 1吴永芳 1邵云 1邰艳红 1李晓兵 1徐建明 3吴世凯 4李虎城2
作者信息
- 1. 军事医学科学院附属医院 病理科，北京 100071
- 2. 军事医学科学院附属医院 普外科，北京 100071
- 3. 军事医学科学院附属医院 消化道肿瘤科，北京 100071
- 4. 军事医学科学院附属医院 放疗科，北京 100071
- 折叠
摘要
Abstract
Objective: To analyze clinicopathological features and observe the pathological types and distribution among intestine neoplasms of digestive system tumors in Affliated Hospital of Academy of Military Medical Sciences, according to the World Health Organization criteria (2010).Methods: Retrospective analysed 2 772 cases of intestine neoplasms, which was diagnosed in Affiliated Hospital of Academy of Military Medical Science from November 2010 to March 2015. All the histopathological slides including HE slides and immunohistochemistryslides were re-examined and the medical records were reviewed.Results: Among the 2 772 cases, there were 201 cases of the small intestine neoplasms (7.25%), which include 58 benign tumors deriving epithelium (adenomas and polyps) (2.09%), 30 precancerous lesions (1.08%), 52 adenocarcinomas of the small intestine (1.88%), 8 neuroendocrine tumors (0.29%), 37 mesenchymal tumors (1.33%), 4 cases were lymphomas (0.14%) and 12 secondary tumors (0.43%). hTere was no obviously difference of incidence between males and females. hTere were 2 571 cases of colon and rectum lesions (92.75%), including 1 353 benign tumors deriving epithelium (adenomas and polyps) (48.81%), 146 precancerous lesions (5.27%), 1 001 carcinomas of the colon and rectum (36.11%), 27 neuroendocrine tumors (0.97%), 2 mixed adenoneuroendocrine cancers (0.07%), 15 mesenchymal tumors (0.54%), 6 lymphomas (0.22%), 17 secondary tumors (0.61%) and 4 tumours of ectopic origin (0.14%), the ratio between males and females were 3:2.KRAS gene mutation rate was 34.62% (126/364),BRAF gene mutation rate was 2.20% (8/364) andNRAS gene mutation rate was 3.96% (4/101).Conclusion: hTere were many kinds of tumors in intestine, most of the malignant small intestines were interstitial tumors and adenocarcinomas, and most of the malignant colon and rectum were tubular adenocarcinomas. hTe mutation rate ofKARS gene is high in colorectal cancer and these mutations predominantly occur in G12D, G12V and G13D.KARS,BRAF andNRAS mutation can guide the rituximab or panitumumab target for therapy.关键词
管状腺癌/间质瘤/神经内分泌肿瘤Key words
tubular adenocarcinoma/interstitial tumor/clinicopathological analysis引用本文复制引用
王海艳,尉承泽,许春伟,吴永芳,邵云,邰艳红,李晓兵,徐建明,吴世凯,李虎城..2772例肠肿瘤临床病理特征分析[J].临床与病理杂志,2016,36(8):1148-1155,8.
