临床与病理杂志2016，Vol.36Issue(8)：1208-1211,4.DOI:10.3978/j.issn.2095-6959.2016.08.031
泛素羧基末端水解酶L3及其与疾病和肿瘤的相关性
Ubiquitin C-terminal hydrolase L3 and its correlation with tumors
摘要
Abstract
Deubiquitinating enzymes (DUBs) play an important role in the regulation of cellular homeostasis, cell proliferation, division as well as apoptosis, etc. Ubiquitin C-terminal hydrolases L3 (UCH-L3), a kind of cysteine protease, is a member of the DUBs family. It catalyzes and releases those attached intact ubiquitin molecules from peptides chain of target proteins to regulate the degradation rate of target protein and recycle the ubiquitin molecules. hTe study on this hydrolases is inadequate up to now. Many DUBs have been shown to participate in a variety of carcinoma progression. High expressions of DUBs in some kinds of disease and tumor indicate their potential role. In this review, we will discuss about the Ubiquitin C-terminal hydrolases L3 and its potential role in disease and cancer.关键词
泛素羧基末端水解酶L3/去泛素化酶/肿瘤Key words
ubiquitin C-terminal hydrolases L3 (UCH-L3)/deubiquitinating enzymes (DUBs)/tumor引用本文复制引用
郑旸(综述),师永红(审校)..泛素羧基末端水解酶L3及其与疾病和肿瘤的相关性[J].临床与病理杂志,2016,36(8):1208-1211,4.基金项目
Foundation item)国家自然科技基金(81360395)。This work was supported by National Natural Science Foundation of China (81360395) （81360395）
