吉林中医药2016，Vol.36Issue(9)：875-879,5.DOI:10.13463/j.cnki.jlzyy.2016.09.004
肥胖痰湿体质与肥胖非痰湿体质、代谢综合征患者血清 NO 相关指标比较研究
Comparison of serum NO and related indexes of obesity:phlegm-dampness constitution, non phlegm-dampness constitution and metabolic syndrome
摘要
Abstract
Objective To investigate the serum concentration of NO and related indexes of obesity with Phlegm-dampness constitution(OPD),compared with obesity with no Phlegm-dampness constitution(ONPD)and Metabolic Syn-drome(MS),so as to reveal the endothelial function of OPD,which can provide guidance for taking precautions against MS and Cardio-cerebrovascular Complications from the perspective of Phlegm-dampness constitution. Methods Four groups of volunteers were chose in this study:33 cases of obesity with Phlegm-dampness constitution(OPD),31 cases of obesity with NO Phlegm-dampness constitution(ONPD),24 cases of metabolic syndrome group(MS),and 25cases of the normal balanced constitution group(N). In each group,we detect obesity related indices such as BMI,WC,F% ,and MS related indices such as DBP,SBP,FPG,TG,HDL-C,LDL-C and TC. We detect NO related indices such as NOS,iNOS, insulin and ralculated the Insulin Resistance Indexes HOMA-IR. Results Compared with the group N,obesity and MS related indices were significantly higher or lower in the group MS(P < 0. 05 or P < 0. 01). In the group ONPD,there were no significant differences in other indices(P >0. 05). In the group OPD,Obesity related indices were significantly higher(P <0. 01),SBP,DBP,TG were significantly higher(P < 0. 05),HDL-C,and HDL-C were significantly lower (P <0. 01),but there were no significant differences with FPG,LDL-C,TC. In group OPD ,Obesity related indices were similar(P >0. 05),and DBP,TG were significantly higher,and other MS indices were similar(P >0. 05)than the group ONPD. As for NO,compared with N,there were no significant differences in ONPD ,but significantly higher in OPD and MS(P <0. 05 or P <0. 01). As for NOS,compared with N,there were no significant differences in ONPD and MS ,but significantly higher in OPD(P <0. 05). As for iNOS,compared with N,there were no significant differences in ONPD , but significantly higher in OPD and MS(P < 0. 05). There were also significant differences between OPD and ONPD (P <0. 05). As for IR,compared with N,there were no statistical significance in ONPD(P >0. 05). Compared with ON-PD,there were also significant differences in OPD and MS(P < 0. 05). Conclusion The persons with OPD have had vascular endothelial dysfunction even not reaching the clinical diagnostic criteria of MS,with the significant differences of NO,iNOS,IR. Obesity whether with Phlegm-dampness constitution is the key risk factor for endothelial dysfunction. So,we should pay close attention to the endothelial function of persons with Phlegm-dampness constitution and give early intervention and treatment,taking advantage of Traditional Chinese Medicine“Preventive Treatment of Disease”,which has important significance for preventing MS and cardio-cerebrovascular complications.关键词
痰湿体质/代谢综合征/内皮功能紊乱/一氧化氮/胰岛素抵抗Key words
phlegm-dampness constitution/metabolic syndrome/endothelial dysfunction/Nitric Oxide/insulin re-sistance分类
医药卫生引用本文复制引用
李玲孺,王济,姚海强,陈禹,李英帅,张妍,王琦..肥胖痰湿体质与肥胖非痰湿体质、代谢综合征患者血清 NO 相关指标比较研究[J].吉林中医药,2016,36(9):875-879,5.基金项目
国家自科学基金青年基金（81503471）；北京中医药大学基本科研业务费面上项目（2015-JYB-JSMS004）。 （）
