吉林中医药2016，Vol.36Issue(9)：925-928,4.DOI:10.13463/j.cnki.jlzyy.2016.09.018
头穴丛刺对阿尔茨海默病大鼠 MAPK 信号的影响
Cluster needling of scalp point therapyon on MAPK signaling pathway of Alzheimerˊs disease rats
摘要
Abstract
Objective To explore the effect of cluster needling of scalp point therapy on erk,jnk and p38 of MAPK signaling pathway of alzheimerˊs disease rats. Methods Establishing model with Alzheimerˊs disease by injec-ting Aβ1-42 oligomer into bilateral hippocampus. Sixty rats were randomized into five groups including blank control group,cluster needling of scalp point group,traditional head acupuncture group,body acupuncture group,and model group,which contains twelve rats in each group. To observe the changes of p-jnk / jnk,p-erk / erk and p-p38 / p38 through immunohistochemical staining. Results It showed marked differences between each treatment group,except-ing body acupuncture group,and the model group(P < 0. 05). While,there was no marked difference between the body acupuncture group and the model group(P > 0. 05). To observe the p-jnk / jnk:there was a statistical difference between each treatment group(P < 0. 05),and the cluster needling of scalp point group showed a better effect. To observe the p-erk / erk:it showed marked differences between body acupuncture group and the cluster needling of scalp point group,as well as the traditional head acupuncture group(P < 0. 05),and the cluster needling of scalp point group showed a better effect;it showed a rising trend comparing cluster needling of scalp point group and traditional head acupuncture group,but no marked differences between two groups(P > 0. 05). To observe the p-p38 / p38:tthere was a statistical difference between each treatment group(P < 0. 05),and the cluster needling of scalp point group showed a better effect. Conclusion The cluster needling of scalp point therapy can improve learning and mem-ory function of Alzheimerˊs disease rats through up-regulating the p-erk / erk and down-regulating the p-jnk / jnk and p-p38 / p38.关键词
头穴丛刺/p-jnk/jnk/p-erk/erk/p-p38/p38Key words
cluster needling of scalp point therapy/p-jnk / jnk/p-erk / erk/p-p38 / p38分类
医药卫生引用本文复制引用
李虹霖,徐飞,夏昆鹏,张淼,王玉珏..头穴丛刺对阿尔茨海默病大鼠 MAPK 信号的影响[J].吉林中医药,2016,36(9):925-928,4.基金项目
黑龙江省自然科学基金（H201476）；黑龙江省博士后流动站资助基金（LBH-Z14199）。 （）
