检验医学与临床2016，Vol.13Issue(17)：2426-2428,2431,4.DOI:10.3969/j.issn.1672-9455.2016.17.007
促性腺激素在诊断女童性早熟中的临床价值
Clinical value of serum gonadotropin levels in the diagnosis of precocious puberty in girls
摘要
Abstract
Objective To study the clinical value of serum gonadotropin levels in the diagnosis of precocious puberty in girls . Methods A total of 137 girls with central precocious puberty(CPP ,n=91) and partial central precocious puberty(PICPP ,n=46) were enrolled from department of endocrinology in Shenzhen children′s hospital .The baseline values and the peak values in stimula‐ting hormone(GnRH) stimulation test of luteinizing hormone(LH) ,follicle stimulating hormone(FSH) and LH/FSH ratio were compared between the two groups .The receiver operating characteristic(ROC)curve was used to analyze the accuracy of LH ,FSH and LH/FSH ratio in the diagnosis of CPP .Results The baseline of serum LH ,FSH and LH/FSH ratio in CPP group were signif‐icantly higher than those in PICPP(P<0 .01) .The area under curve(AUC)of LH ,FSH and LH/FSH ratios among 137 girls were 0 .825 ,0 .723 and 0 .781 respectively .When the baseline of LH was 0 .35 IU/L ,the sensitivity was 76 .9% ,the specificity was 76 .1% .When diagnostic threshold was 1 .52 IU/L ,the specificity was 100 .0% .The peak of serum LH and LH/FSH ratio in CPP group were significantly higher than those in PICPP(P<0 .01) .The AUC of LH and LH/FSH were 0 .981 and 0 .944 respectively . The peak of FSH has no significant difference between CPP and PICPP(P>0 .05) .When the peak of LH was 5 .61 IU/L ,the sen‐sitivity was 94 .6% ,the specificity was 100 .0% .When diagnostic threshold of peak LH/FSH ratio were 0 .62 ,the specificity was 100 .0% .Conclusion When the basal serum L H level is higher than 1 .52 IU/L ,the diagnosis of CPP can be confirmed in combina‐tion with clinical manifestation ,GnRH stimulation test is unnecessary .When the peak LH stimulated by GnRH were 5 .61 IU/L , the diagnosis of CPP can be confirmed .关键词
性早熟/促性腺激素/鉴别诊断/受试者工作特征曲线/女童Key words
precocious puberty/gonadotropin/differential diagnosis/receiver operating characteristic curve/girls引用本文复制引用
曹科,罗小娟,金晨,马东礼,周晨阳,李世兴,刘新刚,张琴,刘霞..促性腺激素在诊断女童性早熟中的临床价值[J].检验医学与临床,2016,13(17):2426-2428,2431,4.基金项目
广东省深圳市科创委资助项目（JCYJ20140416141331504）。 （）
