检验医学与临床2016，Vol.13Issue(17)：2439-2441,3.DOI:10.3969/j.issn.1672-9455.2016.17.012
米非司酮和甲氨蝶呤治疗子宫切口瘢痕妊娠的临床分析
The clinical analysis on 26 uterine scar pregnancy cases under the treatment of mifepristone combined with methotrexate therapy
谢素娟 1赵俪梅 1张琳 1左莉 1傅亚均1
作者信息
- 1. 重庆市北部新区第一人民医院妇产科 401121
- 折叠
摘要
Abstract
Objective To study the effects of mifepristone and methotrexate therapy on uterine scar pregnancy .Methods 52 pa‐tients with uterine scar pregnancy treated in hospital from June 2012 to June 2014 were enrolled in the study ,who were randomly divided into 2 groups control group and observation group .There were 26 patients in each group .The patients in control group were treated with methotrexate ,while the observation group were treated with mifepristone and methotrexate .Curative effect ,adverse re‐action ,time indexes and serum level of β‐human chorionic gonadotropin(β‐HCG) were statistically analyzed .Results The total ef‐fective rate of observation group was 96 .15% ,while that of the control group patients was 69 .23% ,the difference between the two groups was statistically significant(P<0 .05) .Before treatment ,the serum β‐HCG levels of the patients in observation group and control group were (2 375 .36 ± 48 .73) and (2 350 .31 ± 49 .29) IU/L respectively .There was no statistically significant difference between the two groups(P>0 .05) .After 7 days′treatment ,theβ‐HCG levels of the two groups decreased significantly ,and the lev‐el of observation group was significantly lower than the control group(P<0 .05) .The time for the plump to disappear at scar site , length of stay and serum beta hCG clearance time of patients in observation group were (15 .83 ± 4 .56) ,(8 .20 ± 3 .50) ,(7 .35 ± 1 .82)d respectively ,which were shorter than that in control group ,the difference was statistically significant(P<0 .05) .There was no significant difference in the incidence of adverse reactions between the two groups(P>0 .05) .Conclusion Mifepristone in com‐bination with methotrexate used in the treatment of uterine scar pregnancy help patients recover quickly .关键词
米非司酮/甲氨蝶呤/子宫瘢痕/人绒毛膜促性腺激素Key words
mifepristone/methotrexate/uterine scar/human chorionic gonadotropin引用本文复制引用
谢素娟,赵俪梅,张琳,左莉,傅亚均..米非司酮和甲氨蝶呤治疗子宫切口瘢痕妊娠的临床分析[J].检验医学与临床,2016,13(17):2439-2441,3.
