临床口腔医学杂志2016，Vol.32Issue(9)：527-530,4.DOI:10.3969/j.issn.1003-1634.2016.09.005
SSB1在腮腺放射性损伤修复过程中的表达变化
The expression of SSB1 in radioactive damage repair of parotid gland
摘要
Abstract
Objective:To investigate the expression of single⁃strand DNA⁃binding protein 1(SSB1) in rats’normal and irradiated parotid gland tissue,and explore the relationship between SSB1 and radioactive damage repair�Methods:Take the normal rats as control(n=5),the experimental rats(n=40)were radiated with60 Co gamma rays on head and neck region in a dose of 6 Gy�Five rats were randomly killed per hour to form eight experimental groups after irradia⁃tion�Immunohistochemical and RT⁃qPCR were applicated to detect the expression of SSB1 in rats parotid gland�Results:A certain amount of endogenous SSB1 was expressed in normal rats parotid gland tissue�The content of SSB1 was different in different parotid gland tissues,ducts >acinus> connective tissue�SSB1 was displayed a increasing first(P<0�05)and after weakening trend over time after irradiation and the unper expression was close to nomal�Conclusion:SSB1 is a radiation⁃in⁃duced protein,which may be involved in radioactive damage repair process in the rats’ parotid gland.关键词
单链DNA结合蛋白/腮腺/放射性损伤/DSBs修复Key words
Single-strand DNA-binding protein 1/Parotid gland/Radioactive damage/DSBs repair分类
生物科学引用本文复制引用
曾祥林,王代友,蓝铁瓒,曹阳,于萧..SSB1在腮腺放射性损伤修复过程中的表达变化[J].临床口腔医学杂志,2016,32(9):527-530,4.基金项目
广西重点自然科学基金 （）
