临床输血与检验2016，Vol.18Issue(5)：412-415,4.DOI:10.3969/j.issn.1671-2587.2016.05.02
外源性谷氨酰胺对机体抗氧化酶影响的实验研究
An Experimental Study of Exogenous Glutamine Influence on the Antioxidant Enzymes
李大鹏 1翟真真 1张霞 1王凤娇 1郑文哲2
作者信息
- 1. 271000 山东省泰安市解放军第88医院
- 2. 271000 山东省泰安市解放军第88医院医务处
- 折叠
摘要
Abstract
Objective To explore the influence of exogenous glutamine(Gln)on the antioxidant enzymes. Methods Twenty two rats (specific pathogen free) were randomly divided into experimental group(A),control group (B),and standard group(C). Animals of group A received gavage daily with alanyl-glutamine,group B with 0.9%normal saline,and group C were set up as control. Groups A and B were given gavage consecutively for 14 days. Blood specimens of rats of the three groups were detected for hydrogen peroxide enzyme(CAT), superoxide dismutase(SOD) and glutathione oxidation reductase(GSH-Px). Results The difference of CAT between groups A and C was statistically significant(P<0.05), while the level of CAT at 14d of experimental group was significantly higher than the standard group(P<0.05). The difference of GSH-Px between groups A and C was statistically significant(P<0.05), no difference between groups A and B was found(P>0.05).The level of GSH-Px at 14d of experimental group was remarkably higher than that of standard group(P<0.05). No significant difference of SOD was noted among all of the three groups (P>0.05). Conclusion Temperal administration of exogenous Gln may significantly increase CAT and GSH-Px levels, and serum SOD as well,thereby enhancing the ability to scavenge free radicals and antioxidant of the body.关键词
脂质过氧化/自由基/抗氧化酶/过氧化氢酶/超氧化物歧化酶/谷胱甘肽过氧化物酶/谷氨酰胺Key words
Lipid peroxidation/Free radicals/Antioxidant enzyme/Hydrogen peroxide enzyme/Superoxide dismutase/Glutathione oxidation reductase/Glutamine分类
医药卫生引用本文复制引用
李大鹏,翟真真,张霞,王凤娇,郑文哲..外源性谷氨酰胺对机体抗氧化酶影响的实验研究[J].临床输血与检验,2016,18(5):412-415,4.
