临床输血与检验2016，Vol.18Issue(5)：420-423,424,5.DOI:10.3969/j.issn.1671-2587.2016.05.004
广西地区壮族人群Dombrock血型系统抗原基因分布特征的研究
The Characteristic of Gene Polymorphisms of Dombrock Blood Group in Zhuang Nationality from Guangxi Region ;in China in China
摘要
Abstract
Objective To investigate the genetic polymorphisms of Dombrock blood group in Zhuang nationality population in different areas of Guangxi. Methods We analyzed the genotypes of Dombrock blood group in 1 025 non-related Guangxi Zhuang nationality population who live in Wuming, Shanglin, Longan, Binyang, Pingguo, Dahua, Duan, Bama, and Daxin by PCR-SSP typing. Results Three individuals were found to carry Doa(+) homozygote, while 865 cases have Dob(+) homozygote. The Doa gene frequencies of Wuming, Shanglin, Longan, Binyang, Pingguo, Dahua, Duan, Bama, and Daxin was 0.090 9, 0.045 9, 0.090 9, 0.062 5, 0.108 3, 0.054 2, 0.091 7, 0.066 7 and 0.100 0, respectively. The general gene frequency of Doa was 0.079 5,while that of Dob was 0.920 5. Conclusion The distribution feature of Dombrock blood group in Guangxi Zhuang nationality was polymorphic, which is similar to that in Chinese Han population. Doa gene frequency in the population studied, however, is much lower than that in Tibetan and Uyghur nationality.关键词
广西壮族/Dombrock血型系统/基因频率/聚合酶链反应-序列特异性引物Key words
Guangxi Zhuang nationality/Dombrock blood group/Gene frequency/PCR-SSP分类
医药卫生引用本文复制引用
申卫东,周先果,周燕,刘金莲,莫秋红,吴国光..广西地区壮族人群Dombrock血型系统抗原基因分布特征的研究[J].临床输血与检验,2016,18(5):420-423,424,5.基金项目
本课题受广西自然科学基金（No.2010GXNSFA013262），南宁市科学研究与技术开发计划项目（No.201003048C-1），广西省卫生厅自筹经费科研课题（No.Z2010196）资助 （）
