河南科技大学学报（医学版）2016，Vol.36Issue(3)：174-176,3.DOI:10.15926/j.cnki.issn1672-688x.2016.03.004
低氧对大鼠前额叶皮层 AQP4蛋白和 HIF-1α蛋白表达的影响
Effect of Hypoxia on Expression of AQP4 and HIF-1αin Protein in Prefrontal Cortex of Rats
李敏 1董子玉 1陈学群1
作者信息
- 1. 信阳职业技术学院，河南信阳 464000
- 折叠
摘要
Abstract
Objective To investigate the expression of AQP4 and HIF-1 αprotein in the prefrontal cortex of SD rats under hypoxic conditions for the basis of elucidating the mechanism of hypoxic brain edema. Methods Twelve SD rats were randomly divided into the normal oxygen group and the hypoxia group.Rats in hypoxia group were exposed to hypoxia (7.8% O2 ,equal to 7 000 m altitude)in a hypobaric chamber for 8 h.The expression of AQP4 and HIF-1 αprotein in rat prefrontal cortex were determined by Western blot. Results AQP4 and HIF-1 α protein were enhanced in the hypoxic rat prefrontal cortex after exposure to 7 000 m hypoxia for 8 h (P <0.05)by Western blot. Conclusion The expression of AQP4 and HIF-1 αprotein in the prefrontal cortex of SD rats were increased after 8 h hypoxia.It was showed that HIF-1 might contribute to hypoxic brain edema by increasing the expression of AQP4 protein.关键词
低氧/脑水肿/水通道蛋白 4/低氧诱导因子 -1Key words
hypoxia/brain edema/aquaporin 4/hypoxia induced factor-1/HIF-1 α分类
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李敏,董子玉,陈学群..低氧对大鼠前额叶皮层 AQP4蛋白和 HIF-1α蛋白表达的影响[J].河南科技大学学报（医学版）,2016,36(3):174-176,3.
