河南科技大学学报（医学版）2016，Vol.36Issue(3)：180-182,3.DOI:10.15926/j.cnki.issn1672-688x.2016.03.006
白细胞介素12基因 rs3212227多态性与甲状腺乳头状癌的关系
Association of IL-12 rs3212227 Polymorphism with Papillary Thyroid Cancer in a Chinese Population
摘要
Abstract
Objective The aim of the present study was to clarify the role of interleukin-12 (IL-12)gene rs3212227 polymorphism with the risk of papillary thyroid cancer (PTC)in a Chinese population. Methods IL-12 gene rs3212227 polymorphism were genotyped in a case-control study of 21 1 PTC patients and 216 health controls using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results No significant difference was noticed in IL-12 rs3212227 polymorphism between PTC patients and healthy controls in the overall analysis.However,we found that PTC patients carrying the A /C and C /C genotypes in rs3212227 had significantly increased risks for developing extra-thyroidal invasion compared with those carrying the AA genotype (P =0.047,P =0.035,respectively). Conclusion There is no obvious association between IL-12 gene rs3212227 polymorphism and PTC occurance.However,the data elucidate that the rs3212227 polymorphism of IL-12 gene might affect the PTC invasion to thyroid capsule.关键词
IL-12/单核苷酸多态性/甲状腺乳头状癌Key words
IL-12/single nucleotide polymorphism/papillary thyroid cancer分类
医药卫生引用本文复制引用
黄蓉,程晓刚,金虹,马晶..白细胞介素12基因 rs3212227多态性与甲状腺乳头状癌的关系[J].河南科技大学学报（医学版）,2016,36(3):180-182,3.基金项目
2013年省级大学生创新实验计划项目 （）
