河南科技大学学报（医学版）2016，Vol.36Issue(3)：193-195,3.DOI:10.15926/j.cnki.issn1672-688x.2016.03.010
磷酸肌酸钠治疗Ⅳ型心肾综合征的临床观察
Observation of Creatine Phosphate Sodium in the Treatment of Type IV Cardiorenal Syndrome
桂元 1冯幼兰 1徐芳 1詹继东 1王砾1
作者信息
- 1. 华中科技大学校医院内科，湖北武汉 430074
- 折叠
摘要
Abstract
Objective To investigate the effect of creatine phosphate sodium on cardiac function and inflammatory cytokines in patients with type Ⅳ cardiorenal syndrome on the basis of conventional therapy. Methods 72 cases of type Ⅳ cardiorenal syndrome were randomly divided into observation group(38 cases) and control group(32 cases).Control group was used conventional drug therapy,while the observation group was used conventional therapy and creatine phosphate sodium 2.0g,once daily and continuous application of 14d.The serum troponin T (cTnT),creatine kinase isoenzyme (CK-MB ),serum B type brain natriretic peptide(BNP),left ventricular ejection fraction(LVEF),the level of high-sensitivity C-reactive protein(hs-CRP),interleukin-6 (IL-6 )and tumor necrosis factor-α(TNF-α)were observed between the two groups before and after treatment. Results After treatment the level of cTnT,CK-MB and BNP in observation group were significantly reduced than the control group after treatment(P <0.05 ),while the level of LVEF was higher than the control group (P <0.05 ).The level of hs-CRP,IL-6 and TNF-α were significantly reduced after treatment(P <0.05 ),especially in the observation group (P <0.05 ). Conclusion The inflammatory factors activation inhibited by creatine phosphate sodium may be one of the protection mechanisms of type Ⅳ cardiorenal syndrome.关键词
Ⅳ型心肾综合征/磷酸肌酸钠/心功能/炎症介质Key words
type Ⅳ cardiorenal syndrome/creatine phosphate sodium/heart function/inflammatory mediators分类
医药卫生引用本文复制引用
桂元,冯幼兰,徐芳,詹继东,王砾..磷酸肌酸钠治疗Ⅳ型心肾综合征的临床观察[J].河南科技大学学报（医学版）,2016,36(3):193-195,3.
