河南科技大学学报（医学版）2016，Vol.36Issue(3)：196-198,3.DOI:10.15926/j.cnki.issn1672-688x.2016.03.011
双歧杆菌乳杆菌三联活菌片对1型糖尿病肠道菌群和血清 IFN-γ、IL-4的影响
Influence of Live Combined Bifidobacterium and Lactobacillus Tablet for Intestinal Microflora and Serum IFN-γ、IL-4 in Children with Type 1 Diabetes Mellitus
牛文忠 1丁显春1
作者信息
- 1. 南阳市中心医院儿科，河南南阳 473000
- 折叠
摘要
Abstract
Objective To explore the influence of live combined bifidobacterium and lactobacillus tablet for intestinal microflora and serum IFN-γ and IL-4 in children with type 1 diabetes mellitus (T1DM). Methods 25 children with T1DM were selected as observation group from February 2014 to January 2015 in pediatrics department of Nanyang Central Hospital,and 25 healthy children undergoing physical examination at the same time period were selected as control group.All children aged from 3 to 8 years old.The observation group were treated with insulin and live combined bifidobacterium and lactobacillus tablet,0.5 g per time and three times per day for 1 month.The control group were without any treatment.The changes of intestinal microflora,serum IFN-γand IL-4 levels were compared between observation group and control group.In observation group,the changes were compared between pre-treatment and 1 month post-treatment. Results The quantity of bifidobacterium and lactobacillus in observation group was lower than the control group,the level of IFN-γ and IFN-γ/IL-4 in observation group was higher than the control group (P <0.05 );In observation group,the quantity of bifidobacterium and lactobacillus in pre-treatment was lower than post-treatment,the level of IFN-γand IFN-γ/IL-4 in pre-treatment was higher than post-treatment(all P <0.05). Conclusion Live combined bifidobacterium and lactobacillus tablet may improve the intestinal microflora and restore the balance of Th1 /Th2 in children with T1DM.关键词
双歧杆菌乳杆菌三联活菌片/1 型糖尿病/肠道菌群/儿童Key words
live combined bifidobacterium and lactobacillus tablet/type 1 diabetes mellitus/intestinal microflora/children分类
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牛文忠,丁显春..双歧杆菌乳杆菌三联活菌片对1型糖尿病肠道菌群和血清 IFN-γ、IL-4的影响[J].河南科技大学学报（医学版）,2016,36(3):196-198,3.
