国际眼科杂志2016，Vol.16Issue(10)：1800-1804,5.DOI:10.3980/j.issn.1672-5123.2016.10.04
自噬在青光眼和视网膜退行性病变中的研究进展
Study of progress of autophagy in glaucoma and retinal degeneration
梁幼玲 1石晶明 1贾松柏1
作者信息
- 1. 410011 中国湖南省长沙市，中南大学湘雅二医院眼科
- 折叠
摘要
Abstract
Autophagy, a cellular housekeeping process, is indispensable to controlling the homeostasis of cytoplasm by removing unused proteins and damaged cell organelles. This process involves different types of human diseases, including cancers, neurodegenerative diseases and infectious diseases. Neurodegeneration is a critical pathological process of many eye diseases, such as glaucoma and age-related macular degeneration. The retina and all intraocular cells are constantly exposed to environmental stress and injuries, including oxidative stress and starvation, which lead to autophagy. Autophagy promotes cell survival through the recycling of metabolic precursors, or promotes cell death if autophagy is over-active. Additionally, autophagy and apoptosis have been shown to be harmonious or contrasting, depending on different experimental contexts. All of this contributes to the pathogenesis of many diseases. This paper reviews the mechanisms and regulation involved in autophagy, current understandings of neuronal autophagy in glaucoma and retina and strategies for therapeutic modulation.关键词
自噬/青光眼/视网膜退行性病变Key words
autophagy/glaucoma/retinal degeneration引用本文复制引用
梁幼玲,石晶明,贾松柏..自噬在青光眼和视网膜退行性病变中的研究进展[J].国际眼科杂志,2016,16(10):1800-1804,5.
