国际眼科杂志2016，Vol.16Issue(10)：1891-1893,3.DOI:10.3980/j.issn.1672-5123.2016.10.26
Dickkopf-3蛋白在糖尿病视网膜病变患者血浆中的表达
Study on the expression of Dickkopf-3 protein in diabetic retinopathy
摘要
Abstract
AIM:To observe the effects of Dickkopf-3 ( Dkk-3 ) in diabetic retinopathy ( DR ) circulating blood in patients with the expression level, the Dkk - 3 development changes in the diabetic retinopathy of significance in the diagnosis of early DR. <br> ● METHODS: Eighty - five type 2 diabetic patients, included the non - proliferative diabetic retinopathy ( NPDR ) 23 patients, proliferative diabetic retinopathy, proliferative DR ( PDR ) in patients with 30 and non-diabetic retinopathy ( NDR ) with 32 cases. The same period of healthy physical examination was selected as control group ( 80 cases ) . Serum samples were collected, and the relative expression level of Dkk-3 was detected by enzyme - linked immunosorbent assay ( ELlSA) double antibody sandwich assay. The statistical differences were compared between groups. <br> ●RESULTS: The plasma level of Dkk - 3 ( 430. 16 ± 198. 11pg/mL) in DR patients was significantly lower than that in healthy control group (627. 48±294. 45 pg/mL; P<0. 05 ) and NDR patients ( 601. 99 ± 194. 16 pg/mL; P<0. 05). While there was no significant difference in Dkk-3 level between NDR and healthy control group ( P =0. 729). The level of PDR in patients with Dkk-3 (396. 38± 185. 59 pg/mL) was lower than that of NPDR (538. 82 ± 187. 20 pg/mL;P=0. 002). <br> ●CONCLUSION:The decrease of Dkk-3 level may be related to the occurrence and development of diabetic retinopathy, and there is a significant correlation with PDR. Circulating blood Dkk - 3 protein in diabetic retinopathy has a certain differential efficacy, it is likely to become diabetic retinopathy patients peripheral blood test indicators.关键词
糖尿病视网膜病变/Dickkopf-3/循环血液Key words
diabetic retinopathy/Dickkopf-3/circulating引用本文复制引用
李沭岩,张磊,张爱华..Dickkopf-3蛋白在糖尿病视网膜病变患者血浆中的表达[J].国际眼科杂志,2016,16(10):1891-1893,3.基金项目
上海市残疾人康复科研项目资助课题( No. K2014011)@@@@Research Project for Rehabilitation of Disabled People in Shanghai (No. K2014011) （ No. K2014011）
