药学研究2016，Vol.35Issue(9)：529-531,555,4.DOI:10.13506/j.cnki.jpr.2016.09.010
盐酸莫西沙星氯化钠注射液有关物质检查方法研究
Study on related substances in Moxifloxacin Hydrochloride and Sodium Chloride Injection
张锡霞 1李永贵 1王晶1
作者信息
- 1. 山东省药学科学院，山东省化学药物重点实验室，山东 济南 250101
- 折叠
摘要
Abstract
Objective To establish a method for the inspection of related substances in Moxifloxacin Hydrochloride and Sodium Chloride Injection.Methods The determination was carried on a phenysilyl column(4.6 mm×150 mm,5μm) with acetonitrile-saline solution( 30:70)as mobile phase. The detection wavelength was 293 nm. The flow rate was 1. 3 mL·min-1,and the column temperature was 30℃.Results The developed method could be used for the determination of moxifloxacin,known impurities and its degradation products with a good resolution,the system suitability was fine.The impu-rities(A,B,C,D,E)had good linearity.The corresponding correction factor:impurities B=1.42,impurities E=3.40.Conclu-sion The method can be special,sensitive and accurate with good reproducibility for the inspection of related substances in Moxifloxacin Hydrochloride and Sodium Chloride Injection.关键词
莫西沙星/有关物质/校正因子Key words
Moxifloxacin/Related substances/Correction factor分类
医药卫生引用本文复制引用
张锡霞,李永贵,王晶..盐酸莫西沙星氯化钠注射液有关物质检查方法研究[J].药学研究,2016,35(9):529-531,555,4.
