药学研究2016，Vol.35Issue(9)：535-537,544,4.DOI:10.13506/j.cnki.jpr.2016.09.012
健脾祛湿颗粒成型工艺及其急性毒性试验
The forming process and acute toxicity test of Jianpi Qushi Granules
摘要
Abstract
Objective To research the forming process of Jianpi Qushi Granules and its acute toxicity after administra-tion.Methods Adjuvants were definited in forming process,the amount of dextrin and the concentration of ethanol were definited by response surface methodology.After preparation of the samples,the acute toxicity test of Jianpi Qushi Granules in mice were carried out,and definited the acute toxicity according to the death of mice.Results The preparation of Jianpi Qushi Granules was yellow,uniform size,the amounts of excipients were 17% dextrin,90% ethanol.The acute toxicity results was that:the largest dosage was 120 g·kg-1 for single dose in mice.Conclusion The preparation process of Jianpi Qushi Granules with 17% dextrin,90% ethanol was reliable,safe and low toxicity,and suitable for clinical application.关键词
健脾祛湿颗粒/效应面/急性毒性/成型工艺Key words
Jianpi Qushi Granules/Response surface methodology/Acute toxicity/Forming process分类
化学化工引用本文复制引用
冯程,高志惠,王平,田禾,张学顺,孙铁锋..健脾祛湿颗粒成型工艺及其急性毒性试验[J].药学研究,2016,35(9):535-537,544,4.基金项目
济南市科技发展计划重点项目 （）
