药学研究2016，Vol.35Issue(9)：545-547,558,4.DOI:10.13506/j.cnki.jpr.2016.09.015
木丹颗粒联合厄贝沙坦对早期糖尿病肾病血浆转化生长因子β1和同型半胱氨酸的影响：一项随机、开放、平行、对照研究
Effects of Mudan Particles combined with irbesartan on the levels of serum transforming growth factor-β1 and homocysteine in patients with early diabetic nephropathy:A randomized,open,parallel,controlled study
李伟华 1狄会峰 1陈颖颖 1王德宝 1刘鹏1
作者信息
- 1. 莱芜市人民医院，山东 莱芜 271100
- 折叠
摘要
Abstract
Objective To investigate the effects of Mudan Particles combined with irbesartan on the levels of serum transforming growth factor-β1(TGF-β1)and homocysteine(Hcy)in patients with early diabetic nephropathy.Methods Application of prospectively randomized,open,parallel,controlled methods,a total of 72 patients with early diabetic ne-phropathy were selected,and were randomly divided into two groups for Mudan Particles combined with irbesartan (combined therapy)or irbesartan treatment,respectively.Changes in urinary albumin excretion rate(UAER),urine β2-mi-croglobulin(β2-MG),the levels of serum TGF-β1 and Hcy were measured and compared between two groups at both pre-and post-treatment of 48 weeks.Results There were no statistically significant difference in the baseline clinical character-istics of study participants between two treatment groups( P﹥0. 05 ). Comparison of therapy-related differences between groups showed that the combined therapy was better in reducing UAER,urineβ2-MG and serum TGF-β1 than the irbesar-tan group[(-37±12 vs -22±10)μg·min-1,(-0.40±0.17 vs -0.24±0.12)mg·L-1,(-31±15 vs -14±12)U·L-1,re-spectively,all P﹤0.01].Conclusion Compared with irbesartan monotherapy,Mudan Particles combined with irbesartan treatment can better reduce serum TGF-β1 levels,decrease UAER and urine β2-MG,and may exert kidney protection effects in patients with early diabetic nephropathy.关键词
木丹颗粒/糖尿病肾病/转化生长因子β1/同型半胱氨酸Key words
Mudan Particles/Diabetic nephropathy/Transforming growth factor-β1/Homocysteine分类
医药卫生引用本文复制引用
李伟华,狄会峰,陈颖颖,王德宝,刘鹏..木丹颗粒联合厄贝沙坦对早期糖尿病肾病血浆转化生长因子β1和同型半胱氨酸的影响：一项随机、开放、平行、对照研究[J].药学研究,2016,35(9):545-547,558,4.
