山东医药2016，Vol.56Issue(33)：11-13,3.DOI:10.3969/j.issn.1002-266X.2016.33.004
高同型半胱氨酸血症及腹型肥胖对高血压发病的交互作用
Synergistic effect between hyperhomocystinemia and abdominal obesity on incidence of hypertension
摘要
Abstract
Objective To investigate the synergistic effect between hyperhomocystinemia (HHcy)and abdominal obe-sity on the incidence of hypertension.Methods Totally 3 591 subjects were enrolled from health care center.Participants were classified into two groups,namely,non-hypertension group (control group,n =1 235)and hypertension group (n =2 356).A questionnaire survey,physical examination and blood homocysteine (Hcy)test were carried out among the par-ticipants.Results After controlling the age,gender,smoking,alcohol consumption,physical activity and family hyper-tension history,Multiariable Logistic regression analysis showed that the risk of hypertension in patients with abdominal o-besity was 1.54 times higher than that of patients with normal waistline,and the risk of hypertension in patients with HHcy was 2.287 times higher than that of patients with normal Hcy (OR =2.287 and 1.54,all P <0.05).Interaction analysis showed that the risk of patients with HHcy and abdominal obesity was 3.464 times higher than that of patients without HHcy and abdominal obesity.The synergy index between hyperhomocystinemia and abdominal obesity on the incidence of hyper-tension was 1.253,the attributable proportion due to the interaction was 14.3% and the pure attributable proportion due to the interaction was 20.2%.Conclusion HHcy and abdominal obesity are risk factors for hypertension and there is a pos-itive synergistic effect between HHcy and abdominal obesity on the incidence of hypertension.关键词
高血压/高同型半胱氨酸血症/腹型肥胖/交互作用Key words
hypertension/hyperhomocystinemia/abdominal obesity/synergistic effect分类
医药卫生引用本文复制引用
商鲁翔,杨波,王月,韩梅玲,满姗姗,刘振东..高同型半胱氨酸血症及腹型肥胖对高血压发病的交互作用[J].山东医药,2016,56(33):11-13,3.基金项目
山东省自然科学基金资助项目（ZR2014HM098）；山东省医药卫生科技发展计划项目（2014WS0312）。 （）
