山东医药2016，Vol.56Issue(33)：25-27,30,4.DOI:10.3969/j.issn.1002-266X.2016.33.008
Siewert Ⅱ、Ⅲ型胃食管结合部癌的临床特点及 HER2、SKP2表达
Clinical characteristics and expression of HER2 and SKP2 in Siewert Ⅱand Ⅲ adencarcinoma of gastric esophageal junction
刘中元 1张黎2
作者信息
- 1. 济宁市第一人民医院，山东济宁 272100
- 2. 山东大学附属山东省立医院
- 折叠
摘要
Abstract
Objective To invesitgate the clinical characteristics and expression of human epidermal growth factor re-ceptor 2 (HER2)and S-phase kinase-associated protein 2 (SKP2)in Siewert Ⅱ and Ⅲ adencarcinoma of gastric esopha-geal junction (AEG).Methods Totally 206 patients with Siewert II or Ⅲ AEG were selected for comparison of the clini-cal characteristics between the two types.The expression of HER2 and SKP2 was detected by immunohistochemistry.The relationships between positive HER2 and SKP2 expression and the clinical pathologic parameters in Siewert Ⅱ and III AEG were analyzed.Results There were statistically significant differences between the two AEG types in tumor size,lymph node metastasis,differentiation grade and TNMstage (all P <0.05).The positive expression rates of HER2 and SKP2 were respectively 32.9% and 41.2% in patient with Siewert II AEG,and 36.3% and 55.4% in patients with Siewert ⅢAEG;there was statistically significant difference in SKP2 positive expression rate between the two groups (P <0.05).A-mong the patients with Siewert II or Ⅲ AEG,there were statistically significant differences in HER2 positive expression rate between those with tumor size <5 cm and ≥5 cm,those with infiltration depth T1 -T2 and T3-T4 ,those with high-moderate and low differentiation,and between those with lymph node metastasis N0-N1 and N2-N3 (all P <0.05).Conclusion Abnormal expression of HER2 and SKP2 could promote the development and progression of AEG,and thus may provide a new approach for early diagnosis and treatment of AEG.关键词
食管胃结合部腺癌/人表皮生长因子受体2/细胞S期激酶相关蛋白2Key words
adencarcinoma of esophagogastric junction/human epidermal growth factor receptor 2/S-phase kinase-associated protein 2分类
医药卫生引用本文复制引用
刘中元,张黎..Siewert Ⅱ、Ⅲ型胃食管结合部癌的临床特点及 HER2、SKP2表达[J].山东医药,2016,56(33):25-27,30,4.
