山东医药2016，Vol.56Issue(34)：11-13,3.DOI:10.3969/j.issn.1002-266X.2016.34.004
Id-1和 MMP-2表达与结直肠癌临床病理特征及预后的关系
Id-1 and MMP-2 expression in colorectal cancer and their relationship with clinicopathological characteristics and prognosis
摘要
Abstract
Objective To detect the expression of Id-1 and matrix metalloproteinase-2 (MMP-2)in human colorectal adenocarcinoma tissues,and explore their relationships with clinicopathological characteristics and prognosis.Methods The expression levels of Id-1 and MMP-2 in 50 specimens of normal colorectal tissues,30 specimens of colorectal adenoma tissues and 50 colorectal adenocarcinoma tissues were detected by immunohistochemistry,and subsequently the relationships between their expression and clinical-pathological features and prognosis were analyzed.Results The positive expression rates of Id-1 in colorectal normal tissues,adenoma tissues and adenocarcinoma tissues were 24.00%,43.33% and 72.00%,and the positive expression rates of MMP-2 in colorectal normal tissues,adenoma tissues and adenocarcinoma tissues were 24.00%, 43.33% and 72.00%,all P <0.01.The expression of Id-1 and MMP-2 was correlated with the depth of serosa invasion, TNMstages,liver metastasis,lymph node metastasis and vessel invasion,all P <0.05.The expression of Id-1 was positively correlated with the expression of MMP-2 in colorectal adenocarcinoma tissues (r =0.429,P =0.000).The median survival time of Id-1 positive expression and negative expression were 32 months and 43 months,and the median survival time of MMP-2 positive expression and negative expression were 28 months and 45 months,all P <0.05.Cox proportional hazards model analysis showed that the expression of Id-1 and MMP-2 was significantly correlated with the prognosis(all P <0.05). Conclusion Id-1 and MMP-2 is highly expressed in colorectal adenocarcinoma tissues and its expression is related to the occurrence,metastasis and prognosis of colorectal cancer.关键词
结直肠肿瘤/DNA结合分化抑制蛋白1/基质金属蛋白酶2/病理特征/预后Key words
colorectal neoplasms/Id-1/matrix metalloproteinase-2/pathological characteristics/prognosis分类
医药卫生引用本文复制引用
武雪亮,王立坤,薛军,杨东东,屈明,郭飞,杨瑞敏,马鹏程,刘博..Id-1和 MMP-2表达与结直肠癌临床病理特征及预后的关系[J].山东医药,2016,56(34):11-13,3.基金项目
河北省卫计委医学科学研究重点课题计划（20150058）；河北省科技支撑计划项目（152777237）；河北省张家口市科技局指令性计划（1311055D）。 （）
