山东医药2016，Vol.56Issue(35)：1-4,4.DOI:10.3969/j.issn.1002-266X.2016.35.001
非吸烟女性肺腺癌患者肿瘤组织 EGFR 基因突变、miR-25表达与生理生育特征的关系
Relationships between EGFR mutation, MiR-25 expression and female physiology and fertility factors in female patients with non-smoking lung adenocarcinoma
摘要
Abstract
Objective To investigate the correlations between epidermal growth factor receptor ( EGFR) mutation, ex-pression of miR-25 and female physiology and fertility factors in female patients with non-smoking lung adenocarcinoma. Methods We collected the female physiology and fertility factors ( age, menarche age, menopausal status, age of meno-pause, the number of live births and menstrual period) in 130 female patients with non-smoking lung adenocarcinoma.We detected EGFR mutation by using DNA sequencing technology and the expression of miR-25 by real-time quantitative PCR. The correlations between EGFR mutation, the expression of miR-25 and female physiology and fertility information were detec-ted by chi-square test, Logistics regression and Wilcoxon rank test, respectively.Results There were 71 patients with EG-FR mutation, and 59 cases with wild type EGFR in 130 female patients.EGFR mutation was not related with age, menopaus-al status, age of menopause, the number of live births and menstrual period (all P>0.05), but was related with female men-arche age (P=0.041).The adjusted Logistics regression analysis showed that the patients with menarche age more than 14 years old were not more likely to EGFR mutation than those of menarche age less than 14 years old (OR=0.376, 95%CI=0.146-0.970).The miR-25 expression was not related with age, female physiology and fertility factors of patients.Conclu-sions EGFR mutation is associated with female menarche age in female patients with non-smoking lung adenocarcinoma. However, there is no correlation between the expression of miR-25 and female physiology and fertility factors.关键词
肺肿瘤/肺腺癌/表皮生长因子受体突变/微小RNA-25Key words
lung neoplasms/lung adenocarcinoma/epidermal growth factor receptor mutation/microRNA-25分类
医药卫生引用本文复制引用
李晶鑫,张寰,许芳秀,王玉,钱碧云..非吸烟女性肺腺癌患者肿瘤组织 EGFR 基因突变、miR-25表达与生理生育特征的关系[J].山东医药,2016,56(35):1-4,4.基金项目
国家自然科学基金资助项目（81573231）；天津市自然科学基金资助项目（13JCYBJC23100）。 （）
