护理研究2016，Vol.30Issue(27)：3352-3355,4.DOI:10.3969/j.issn.1009-6493.2016.27.009
利伐沙班与间歇充气加压泵联合弹力袜法两种方案对病人凝血功能的影响
Influence of two different methods of Rivaroxaban and intermittent pneumatic compression pump combined with e-lastic socks on coagulation function of patients
摘要
Abstract
Objective:The aim was to compare effects of Rivaroxaban and intermittent pneumatic compression pump combined with elastic socks on the coagulation function of patients with venous thromboembolism after lumbar fusion operation.Methods:A total of 158 patients after lumbar fusion operation in our hospital from March 2014 to September 2014 were randomly divided into group A(n=85)and group B(n=73),Patients in group A were taken orally Rivaroxaban for 7 days continuously,12 h after surgery 10 mg per day.Patients in group B were used intermittent pneumatic compression device,30 min each time,2 times a day,from the first postoperative day to postoperative 7 days.And double lower limbs long legs elastic socks were used.Preventive measure of all patients were stopped at 7 d after operation.Coagulation six items prothrombin time(PT),activa-ted partial thromboplastin time(APTT),antithrombin(at),D dimer,thrombin time(TT),fibrinogen(FIB) were detected on before operation and postoperative 7 days.Double lower limb blood vessel ultrasound examina-tion were dene.After operation,we should observe and record 48 h drainage,pay attention to bleeding complica-tions,lower limb swelling and other venous thromboembolism(VTE)signs.Results:No VTE and no bleeding complications occurred 7 d after operation in two groups.There were no significant differences in 48 h drainage, PT,APTT and AT between the two groups.In group A and group B,D dimer on postoperative 7 days were in-creased 3.6 times and 7.4 timesthanthat of before operation.And there was statistically significant difference between two groups and within groups(P<0.05).In group B and group A,FIB were increased by 49.9% and 51.8% respectively.There was no significant difference between two groups on postoperative 7 days(P>0.05). There were statistically significant differences between the postoperative 7 days and before operation(P<0.05).TT on postoperative 7 days was lower than that of before operation 9.4% in group A.There was no change between postoperative 7 days and before operation in group B.There was no significant difference within groups on post-operative 7 days(P>0.05).Conclusion:Effect of preventing VTE of two methods of Rivaroxaban and intermit-tent pneumatic compression pump combined with elastic socks is quiter the same.After application of Rivaroxa-ban,effect of PT,APTT,AT,FIB and other blood coagulation function of patients are small.Clinical observa-tion was without bleeding complications and no increase risk of bleeding.And it has a significant advantage in the D dimer level control.关键词
凝血功能/腰椎融合术/利伐沙班/间歇充气加压泵/弹力袜Key words
coagulation function/lumbar fusion operation/Rivaroxaban/intermittent pneumatic pressure pump/elastic socks分类
医药卫生引用本文复制引用
冯诚诚,张正丰,罗春梅..利伐沙班与间歇充气加压泵联合弹力袜法两种方案对病人凝血功能的影响[J].护理研究,2016,30(27):3352-3355,4.基金项目
2012年第三军医大学新桥医院临床护理科研基金资助课题,编号:201208 （）
