实用肝脏病杂志2016，Vol.19Issue(5)：616-619,4.DOI:10.3969/j.issn.1672-5069.2016.05.030
坏死性凋亡在肝炎以及其他肝病发病中的作用研究进展
Necroptosis and its role in hepatitis and other liver diseases
摘要
Abstract
Traditionally cell death is divided into two categories,e.g. apoptosis and necrosis. But a growing body of research results show that the necrotic apoptosis is a kind of cell death different from necrosis and apoptosis,and plays an important role in a variety of diseases. Activation of necroptosis by ligands of death receptors requires the kinase activity of RIP1,which mediates the activation of RIP3 and MLKL,two critical downstream mediators of necroptosis. Blocking the kinase activity of RIP1,a key druggable target in the necroptosis pathway,by necrostatins inhibits the activation of necroptosis and allows cell survival and proliferation in the presence of death receptor ligands. In this review,we will discuss the difference between apoptosis,necrosis and necrotizing apoptosis,and we will summarizes the mechanism by which the necrotizing apoptosis occur in liver diseases.关键词
肝炎/坏死性凋亡/坏死/凋亡Key words
Hepatitis/Necroptosis/Necrosis/Apoptosis引用本文复制引用
宋金玥,任锋(综述),张桓虎(审校)..坏死性凋亡在肝炎以及其他肝病发病中的作用研究进展[J].实用肝脏病杂志,2016,19(5):616-619,4.基金项目
国家125科技重大专项（编号2012ZX10002004-006/2012ZX10004904-003-001/2013ZX10002002-006-001）；国家自然科学基金项目（编号81270532）；北京市自然科学基金项目（编号7162085）；首都临床特色应用研究项目（编号Z161100000516113）；王宝恩肝纤维化研究基金项目（编号CFHPC20131031）；北京市卫生系统高层次卫生技术人才培养计划 （）
