心脑血管病防治2016，Vol.16Issue(4)：267-269,272,4.DOI:10.3969/j.issn.1009-816x.2016.04.07
依那普利口颊黏膜给药系统：制备和表征
Buccal Mucosa Drug Delivery Systems of Enalapril：Preparation and Characterization
贺文帅 1赵兴胜 1南景龙 1鲁亚南 1温霞 1蔡佳飞2
作者信息
- 1. 010017 内蒙古自治区人民医院心内科
- 2. 028000 内蒙古通辽市疾病控制中心
- 折叠
摘要
Abstract
Objective To study the preparation of buccal mucosa delivery systems of enalapril .Methods Using solvent coating tech-nology and mucous membrane adhesive polymer ,enalapril were prepared in forms of buccal mucoadhesive films .Meanwhile ,their various physical and chemical characteristics were evaluated in release and permeability studies in vitro .Results All formulas showed high percentage composition of drug (96 .45 ~ 98 .49% ) .The formula with good expansion characteristics displayed favorable resi-dence time .In vitro ,the rate of drug release in sodium carboxymethyl cellulose with high viscosity (SCMC HV) ,including mucoad-hesive film (F2) ,was the highest (fast drug release ,with 92 .24% in 1 .5 hours) ,followed by mucoadhesive film F4 (containing polyvinylpyrrolidone K 90 1% w/v ,SCMC (HV) 1% w/v) .It was found that by the end of 10 hours ,drug penetration rate of F2 and F4 in vitro were 82 .24% and 89 .90% respectively .Conclusions In view of the highest degree of expansion ,the maximum ab-sorption and the longest residence time in vitro ,the formula F4 was adopted in the preparation of buccal mucosa delivery system , which could be applied in the treatment of cardiovascular disease .关键词
依那普利/口颊黏膜/制备Key words
Enalapril/Buccal mucosa/Preparation分类
医药卫生引用本文复制引用
贺文帅,赵兴胜,南景龙,鲁亚南,温霞,蔡佳飞..依那普利口颊黏膜给药系统：制备和表征[J].心脑血管病防治,2016,16(4):267-269,272,4.
