中国医疗设备2016，Vol.31Issue(9)：9-13,5.DOI:10.3969/j.issn.1674-1633.2016.09.003
一种评估肱动脉内皮功能的电阻抗信号检测与分析系统
Detecting andAnalyzing System for BrachialArtery Endothelial Function
摘要
Abstract
The damage or dysfunction of arterial endothelial function is the primary performance at the early stage of atherosclerosis. Quantitative evaluation of brachial artery endothelial function is helpful to discover the cardiovascular dysfunction in time, thus provides some evidence for the early diagnosis and treatment of cardiovascular and cerebrovascular diseases. To date, brachial artery endothelial function is evaluated at clinic by measuring the brachial flow-mediated vasodilation (FMD) with a Color Doppler Ultrasonography. Although the accuracy and resolution of this method are much higher, its equipment is relatively expensive, and its operation is very complicated. In this study, a detecting and analyzing system is proposed for evaluating brachial artery endothelial function based on forearm biological electrical impedance signal. By detecting forearm biological impedance signal before and after brachial FMD, the characteristic parameters of biological electro-impedance signals, including characteristic frequency, absolute energy, average amplitude and their relative alteration rate, are calculated using wavelet analysis technology. As the changes in the forearm biological electro-impedance before and after FMD are mainly caused by the changes in the brachial arterial diameter, the detecting and analyzing system of forearm biological electro-impedance signal would provide a new idea for evaluating quantitatively brachial artery endothelial function. In comparison with existing methods at clinic, the detecting and analyzing system of forearm biological electro-impedance signal is detection-simpler, cheaper, more practical and convenient, it can not only be used in the family or community medicine, but also realize on-line detection and provide with a methodology base for further development of the intelligent and wearable electrical impedance analyzer for monitoring arterial function.关键词
肱动脉内皮功能/生物电阻抗信号/小波分析/特征频率/绝对能量/平均幅值Key words
arterial endothelial function/biological impedance signal/wavelet analysis/characteristic frequency/absolute energy/average amplitude分类
信息技术与安全科学引用本文复制引用
李思琦,申华,朱勇,梁舜,覃开蓉..一种评估肱动脉内皮功能的电阻抗信号检测与分析系统[J].中国医疗设备,2016,31(9):9-13,5.基金项目
国家自然科学基金项目（31370948）；辽宁省公益研究科学基金项目（2014001027）。 （）
