中国医疗设备2016，Vol.31Issue(9)：57-59,3.DOI:10.3969/j.issn.1674-1633.2016.09.014
64排螺旋CT联合高敏C反应蛋白、基质金属蛋白酶-9法在冠脉斑块性质检测中的应用
Combined Application of 64-Row Spiral CT, High Sensitivity C-Reactive Protein and Matrix Metalloproteinase-9 in Diagnosis of Acute Coronary Syndrome Plaques
摘要
Abstract
Objective To explore the effectiveness of combination of application of 64-row spiral CT coronary artery imaging, high sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9) in detection of vulnerable plaques in patients with acute coronary syndromes (ACS). Methods A total of 112 cases of hospitalized patients with coronary heart disease (CHD) who had single coronary plaque and were treated in the hospital between September 2014 and March 2014 were selected and divided into two groups (Observation 1 Group, Observation 2 Group and Control Group) according to the condition of CHD. Among all the patients, 50 cases of patients with stable angina pectoris (SAP) were selected as Observation 1 Group, 62 patients with ACS as Observation 2 Group, 86 cases of healthy patients whose KPS (Karnofsky Performance Score) ≥ 90 points as Control Group. The three groups of patients were scanned by using 64-row spiral CT coronary artery imaging so as to observe the concentration of hs-CRP and MMP-9 and the distribution of arterial plaques. Results Compared with Control Group, Observation 1 Group and Observation 2 Group showed obviously increasing hs-CRP and MMP-9 concentrations (P<0.05), among which Observation 2 Group had the highest concentration (P<0.05); more soft plaques were found in Observation 2 Group than Control Group (P<0.05); hs-CRP and MMP-9 concentrations of all patients with CHD were negatively correlated with CT values (P<0.05). Conclusion Combination of application of hs-CRP, MMP-9 and CT coronary imaging showed excellent effectiveness in detection of vulnerable plaques in patients with ACS, which greatly improved the accuracy in diagnosis of ACS.关键词
CT/高敏C反应蛋白/金属蛋白酶-9/急性冠脉综合征/稳定性心绞痛Key words
computerized tomography/high sensitivity C-reactive protein/matrix metalloproteinase -9/acute coronary syndrome/stable angina pectoris分类
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刘沛国,伊旭,李京津,王玉君,牛心刚,韩燕,苏志刚..64排螺旋CT联合高敏C反应蛋白、基质金属蛋白酶-9法在冠脉斑块性质检测中的应用[J].中国医疗设备,2016,31(9):57-59,3.基金项目
秦皇岛市科学技术研究与发展计划项目 （）
