摘要
Abstract
Objective To investigate the application value of monocyte chemoattractant protein-1 ( MCP-1 ) , macro-phage stimulating protein ( MSP) , serum leptin ( LEP) in the identification of lung cancer and tuberculosis .Methods 50 ca-ses of sputum smear diagnosed as tuberculosis and 50 cases of histologically diagnosed as lung cancer , 45 cases of healthy peo-ple were selected as control group from January 2015 to December 2015.The levels of MCP-1, MSP, LEP of three groups were measured by ELISA method .The value of MCP-1, MSP, LEP in identification of lung cancer and tuberculosis were de-termined with Receiver Operating Characteristic (ROC).Results Blood samples were tested: The levels of MCP-1, MSP, LEP of lung cancer and tuberculosis were higher than control group ( P <0.05).Compared with tuberculosis group, the level of LEP of lung cancer group was higher ( P <0.05), the level of MCP-1 was lower ( P <0.05), while MSP had no signifi-cant changes ( P >0.05).Detection of pleural effusion:the levels of MSP, LEP of lung cancer group were higher than tuber-culosis group ( P <0.05), whereas MCP-1 was lower than tuberculosis group ( P <0.05).ROC analysis showed that in the diagnosis of lung cancer , when MSP was 470 pg/ml, the sensitivity (91.1%) of MSP in pleural effusion was the highest , and the specificity was highest (94.2%) at 1 200 pg/ml.In diagnosis of pulmonary tuberculosis , when MCP-1 was 500 pg /ml, the sensitivity (94.5%) was the highest, and the specificity (93.2%) was the highest at 1 100 pg /ml.Conclusion Com-bined detection of MCP-1, MSP and LEP in the pleural fluid can effectively discriminate tuberculosis and lung cancer , and the sensitivity is high , so it is worthy of clinical application and promotion .关键词
单核细胞趋化蛋白-1/巨噬细胞刺激蛋白/瘦素/肺癌/肺结核/鉴别诊断Key words
Monocyte chemoattractant protein-1/Macrophage stimulating protein/Serum leptin/Lung cancer/Tuber-culosis/Differential diagnosis
