中国当代儿科杂志2016，Vol.18Issue(9)：821-825,5.DOI:10.7499/j.issn.1008-8830.2016.09.007
重症化脓性脑膜炎儿童血CD4+CD25+调节性T细胞的变化
Changes in blood CD4+CD25+ regulatory T cells in children with severe purulent meningitis
许巍 1尹苗 1霍明超 1颜景礼 1杨洋 1刘春峰1
作者信息
- 1. 中国医科大学附属盛京医院儿科，辽宁 沈阳 110004
- 折叠
摘要
Abstract
ObjectiveTo preliminarily study the changes in CD4+CD25+ regulatory T cells (Tregs) in children with severe purulent meningitis at the early stage and its possible implications.MethodsA retrospective analysis was performed on the clinical data of 39 children with severe purulent meningitis who were admitted to the pediatric intensive care unit from August 2014 to December 2015. According to whether Tregs count was decreased within 12 hours of hospitalization (considering Tregs count <410/mm3 as decreased), they were divided into two groups: decrease group and non-decrease group. The associations between the changes in Tregs cells and the clinical manifestations, laboratory marker levels, and prognosis were analyzed.ResultsOf the 39 cases, 13 (33%) showed a decrease in the proportion of Tregs cells (<31%) and 18 (46%) showed a decrease in the absolute Tregs cell count (<410/mm3). Four deaths were all in the Tregs decrease group. Compared with the non-decrease group, the decrease group showed a signiifcantly higher proportion of children with a peripheral blood leukocyte count lower than the normal range and a signiifcantly greater increase in the level of serum procalcitonin (P<0.05).ConclusionsTregs might be suppressed in children with severe purulent meningitis at the early stage. And its suppression could be related to the severer inlfammation reaction and higher mortality in those patients.关键词
CD4+CD25+调节性T 细胞/化脓性脑膜炎/儿童Key words
CD4+CD25+ regulatory T cell/Purulent meningitis/Child引用本文复制引用
许巍,尹苗,霍明超,颜景礼,杨洋,刘春峰..重症化脓性脑膜炎儿童血CD4+CD25+调节性T细胞的变化[J].中国当代儿科杂志,2016,18(9):821-825,5.
