中国康复理论与实践2016，Vol.22Issue(9)：1011-1014,4.DOI:10.3969/j.issn.1006-9771.2016.09.005
电针对慢性应激抑郁模型大鼠海马磷酸二酯酶4及其亚型表达的影响
Effect of Electroacupuncture on Expression of Phosphodiesterase 4 and Subtypes in Hippocampus in Rats with Chronic Stress Depression
摘要
Abstract
Objective To explore the biological mechanisms of electroacupuncture (EA) for depression. Methods Forty male adult Sprague-Dawley rats were randomly divided into control group (n=8), model group (n=8), EA group (n=8) and fluoxetine group (n=8). De-pressive models were established with lonely raising and chronic unpredictable mild stress. They were tested with Open-field Test, and the expression of phosphodiesterase 4 (PDE4)A and PDE4D in hippocampus was detected with RT-PCR. Results The cross and rear scores were significantly lower in the model group than in the control group (P<0.001), while it increased in the EA group and the fluoxetine group (P<0.001). Compared with the model group, the expression of PDE4A and PDE4D decreased in the EA group (P<0.001). Conclusion Elec-troacupuncture may relieve depression through inhibiting the expression of PDE4A and PDE4D.关键词
抑郁/电针/慢性应激/磷酸二酯酶4/大鼠Key words
depression/electroacupuncture/chronic stress/phosphodiesterase 4/rats分类
医药卫生引用本文复制引用
景泉凯,赛音朝克图,姚海江,吕威,奥村悠斗,杨利娟,刘俊彤,李志刚..电针对慢性应激抑郁模型大鼠海马磷酸二酯酶4及其亚型表达的影响[J].中国康复理论与实践,2016,22(9):1011-1014,4.基金项目
1.国家自然科学基金地区科学基金项目(No.81360576)；2.国家自然科学基金项目(No.8172860)；3.内蒙古自治区自然科学基金项目(No.2015MS08130)。 （No.81360576）
