中国免疫学杂志2016，Vol.32Issue(9)：1338-1341,4.DOI:10.3969/j.issn.1000-484X.2016.09.020
戴氏绿僵菌多糖对糖尿病模型小鼠血糖和免疫功能的影响
Effect of Metarhiziun taii polysaccharide on serum glucose and immune function of diabetic mellitus model mics
摘要
Abstract
Objective:To investigate the effects of Metarhiziun taii polysaccharide on the immunity activity of the diabetic mellitus model mouse.Methods:To build stables type Ⅰ diabetic model mouse by intraperitoneal injecting small dose streptozotocin ( STZ) continuously.Then observeing weight changes,detecting empty stomach serum glucose,immune organ index( include spleen and thymus),peritoneal macrophage phagocyte ability,spleen lymphocyte multiplication and immunoglobulin IgG′s and complement C3,C4 content in blood serum of the diabetic rats.Results:The weight of model mouse had been improved by Metarhiziun taii polysaccharide, serum glucose had been improved degrade of the ability of model mouse.T,B lymphocyte proliferation had been increased obviously by middle and high dose polysaccharid,spleen index,IgG′s and C3,C4 content in blood serum of the diabetic rats could be improved by high dose distinctively.Thymus index and the capacity of peritoneal macrophage phagocyte would enhanced by middle and high dose polysaccharide inject.Conclusion:The immune function and serum glucose of typeⅠdiabetic mode rats could be improved by intra-gastriced Metarhiziun taii polysaccharide.关键词
戴氏绿僵菌/多糖/糖尿病模型/链脲佐菌素Key words
Metarhiziun taii/Polysaccharide/Diabetic mellitus model/STZ分类
医药卫生引用本文复制引用
肖代敏,吕纯莉,肖建辉,曹喻,张志敏,刘民..戴氏绿僵菌多糖对糖尿病模型小鼠血糖和免疫功能的影响[J].中国免疫学杂志,2016,32(9):1338-1341,4.基金项目
本文为贵州省科技厅基金（黔科合 J字［2009］2148号）和贵州省科技厅联合基金（黔科合J字LKZ［2011］35号）项目。 （）
